References
Avramopoulos
D
(2018) Recent advances in the genetics of schizophrenia. Molecular Neuropsychiatry
4: 35–51.
Balu
DT
(2016) The NMDA receptor and schizophrenia: from pathophysiology to treatment. Advances in Pharmacology
76: 351–382.
Bertelsen
A
,
Harvald
B
and
Hauge
M
(1977) A Danish twin study of manic‐depressive disorders. British Journal of Psychiatry
130: 330–351.
Cannon
M
,
Jones
PB
and
Murray
RM
(2002) Obstetric complications and schizophrenia: historical and meta‐analytic review. American Journal of Psychiatry
159: 1080–1092.
Cannon
TD
(2015) How schizophrenia develops: cognitive and brain mechanisms underlying onset of psychosis. Trends in Cognitive Science
19: 744–756.
Craddock
N
and
Jones
I
(1999) Genetics of bipolar disorder. Journal of Medical Genetics
36: 585–594.
Craddock
N
and
Owen
MJ
(2010) The Kraepelinian dichotomy – going, going…but still not gone. British Journal of Psychiatry
196: 92–95.
Drago
A
,
Crisafulli
C
,
Calabrò
M
, et al. (2015) Enrichment pathway analysis. The inflammatory genetic background in bipolar disorder. Journal of Affective Disorders
179: 88–94.
Feist
GJ
(1999) The influence of personality on artistic and scientific creativity. In: Handbook of Creativity, pp. 273–296. Cambridge University Press: Cambridge.
Flensborg‐Madsen
T
,
Sørensen
HJ
,
Revsbech
R
, et al. (2013) Early motor developmental milestones and level of neuroticism in young adulthood: a 23‐year follow‐up study of the Copenhagen Perinatal Cohort. Psychological Medicine
43: 1293–301.
Friston
KJ
(1998) The disconnection hypothesis. Schizophrenia Research
30: 115–125.
Gejman
PV
(1997) Ernst Rüding and Nazi euthanasia: another stain on his career. American Journal of Medical Genetics
74: 455–456.
Goldman‐Rakic
PS
(1994) Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences
6: 348–357.
Gottesman
II
and
Shields
J
(1967) A polygenic theory of schizophrenia. Proceedings of the National Academy of Sciences
58: 199–205.
Gross
RT
and
Duke
PM
(1980) The effect of early versus late physical maturation on adolescent behavior. Pediatric Clinics of North America
27: 71–77.
Häfner
H
,
Maurer
K
,
Trendler
G
, et al. (2005) The early course of schizophrenia and depression. European Archives of Psychiatry and Clinical Neurosciences
255: 167–173.
Hegyi
H
(2017) Connecting myelin‐related and synaptic dysfunction in schizophrenia with SNP‐rich gene expression hubs. Scientific Reports
7: 45494.
Heston
LL
(1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry
112: 819–825.
Insel
T
,
Cuthbert
B
,
Garvey
M
, et al. (2010) Research domain criteria (RDoC): toward a new classification framework in mental disorders. American Journal of Psychiatry
167: 748–751.
Jablensky
A
(1999) The conflict of the nosologists: views on schizophrenia and manic‐depressive illness in the early part of the 20th century. Schizophrenia Research
39: 95–100.
Jaffe
AE
,
Straub
RE
,
Shin
JH
, et al. (2018) Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nature Neuroscience
21: 1117–1125.
Javitt
DC
(1987) Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia. The Hillside Journal of Clinical Psychiatry
9: 12–35.
Jones
HJ
,
Stergiakouli
E
,
Tansey
KE
, et al. (2016) Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry
73: 221–228.
Kendler
KS
(2016) The schizophrenia polygenic risk score: to what does it predispose in adolescence?
JAMA Psychiatry
73: 193–194.
Kety
SS
,
Rosenthal
D
,
Wender
PH
and
Schulsinger
F
(1968) The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In:
Rosenthal
D
and
Kety
SS
(eds) The Transmission of Schizophrenia, pp. 345–362. New York: Pergamon Press.
Lewis
CM
,
Levinson
DF
,
Wise
LH
, et al. (2003) Genome scan meta‐analysis of schizophrenia and bipolar disorder, part II: schizophrenia. American Journal of Human Genetics
73 (1): 34–48. https://www.sciencedirect.com/science/article/pii/S0002929707638932.
Lieberman
JA
(1999) Is schizophrenia a neurodegeneratise disorder? A clinical and neurobiological perspective. Biological Psychiatry
46: 729–739.
Mendlewicz
J
and
Rainer
JD
(1977) Adoption study supporting genetic transmission in manic‐depressive Illness. Nature
268: 327–329.
Mistry
S
,
Harrison
JR
,
Smith
DJ
, et al. (2018) The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: a systematic review. Journal of Affective Disorders
234: 148–155.
Mitchell
PB
(2012) Bipolar disorder: the shift to overdiagnosis. Canadian Journal of Psychiatry
57: 659–665.
Moises
HW
,
Wollschläger
D
and
Binder
H
(2015) Functional genomics indicate that schizophrenia may be an adult vascular‐ischemic disorder. Translational Psychiatry
5: e616.
Moises
H
(2016) In memoriam of Professor Irving Gottesman (1930–2016). European Archives of Psychiatry and Clinical Neuroscience
266 (6): 581–582.
Moises
HW
,
Yang
L
,
Kristbjarnarson
H
, et al. (1995) An international two‐stage genome‐wide search for schizophrenia susceptibility genes. Nature Genetics
11: 321–324.
Müller
N
,
Weidinger
E
,
Leitner
B
, et al. (2015) The role of inflammation in schizophrenia. Frontiers in Neuroscience
9: 372.
Müller‐Hill
B
(1998) Murderous Science: Elimination by Scientific Selection of Jews Gypsies, and Others in Germany, 1933–1945. Cold Spring Harbor: Cold Spring Harbor Laboratory Press.
van
Os
J
,
Kenis
G
and
Rutten
BP
(2010) The environment and schizophrenia. Nature
468 (7321): 203–212.
Pardiñas
AF
,
Holmans
P
,
Pocklington
AJ
, et al. (2018) Common schizophrenia alleles are enriched in mutation‐intolerant genes and in regions under strong background selection. Nature Genetics
50: 381–389.
Parnas
J
,
Schulsinger
F
,
Teasdale
TW
, et al. (1982) Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry
140: 416–420.
Pers
TH
,
Timshel
P
,
Ripke
S
, et al. (2016) Comprehensive analysis of schizophrenia‐associated loci highlights ion channel pathways and biologically plausible candidate causal genes. Human Molecular Genetics
25: 1247–1254.
Power
RA
,
Steinberg
S
,
Bjornsdottir
G
, et al. (2015) Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience
18: 953–955.
Schijven
D
,
Kofink
D
,
Tragante
V
, et al. (2018) Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling. Schizophrenia Research
199: 195–202.
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia‐associated genetic loci. Nature
511: 421–427.
Stamps
JA
(2007) Growth‐mortality tradeoffs and ‘personality traits’ in animals. Ecology Letters
10: 355–363.
Sullivan
PF
(2017) Schizophrenia and the dynamic genome. Genome Medicine
9: 22.
Tsuchiya
KJ
,
Byrne
M
and
Mortensen
PB
(2003) Risk factors in relation to an emergence of bipolar disorder: a systematic review. Bipolar Disorders
5: 231–242.
Ursini
G
,
Punzi
G
,
Chen
Q
, et al. (2018) Convergence of placenta biology and genetic risk for schizophrenia. Nature Medicine
24: 792–801.
Weber
MM
(1993) Ernst Rüdin. A Critical Biography[in German]. Heidelberg: Springer.
Weinberger
DR
and
Levitt
P
(2011) Neurodevelopmental origins of schizophrenia. In:
Weinberger
DR
and
Harrison
P
(eds) Schizophrenia, pp. 393–412. Chichester: Wiley‐Blackwell.
Wender
PH
,
Kety
SS
,
Rosenthal
D
, et al. (1986) Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Archives of General Psychiatry
43: 923–929.
Xu
MQ
,
Sun
WS
,
Liu
BX
, et al. (2009) Prenatal malnutrition and adult schizophrenia: further evidence from the1959–1961 Chinese famine. Schizophrenia Bulletin
35: 568–576.
Zerbin‐Rüdin
E
and
Kendler
KS
(1996) Ernst Rüdin (1874–1952) and his genealogic–demographic department in Munich (1917–1986): an introduction to their family studies of schizophrenia. American Journal of Medical Genetics
67: 332–337.
Further Reading
Abel
T
and
Nickl‐Jockschat
T
(eds) (2016) The Neurobiology of Schizophrenia, 1st edn.
London: Academic Press.
Breen
G
,
Li
Q
,
Roth
BL
, et al. (2016) Translating genome‐wide association findings into new therapeutics for psychiatry. Nature Neuroscience
19: 1392–1396.
Charney
DS
,
Nestler
EJ
,
Sklar
P
and
Buxbaum
JD
(2018) Neurobiology of Mental Illness, 5th edn.
Oxford: Oxford University Press.
Cryan
JF
and
Reif
A
(2012) Behavioral Neurogenetics. Heidelberg: Springer.
Falkai
P
and
Schmitt
A
(2016) News from the graveyard: neuropathological research on schizophrenia is alive and productive. Schizophrenia Research
177: 1–2.
Gottesman
II
(1991) Schizophrenia Genesis. New York, NY: WH Freeman.
Goodwin
FK
and
Jamison
KR
(2007)
Manic‐Depressive Illness: Bipolar Disorders and Recurrent Depression
, 2nd edn.
New York, NY: Oxford University Press.
Hales
RE
(ed.) (2015) Schizophrenia Spectrum and Other Psychotic Disorders: DSM‐5 Selections. Washington, DC: American Psychiatric Publishing.
McGuffin
P
(2017) Irving Gottesman: American psychologist and behaviour geneticist who radically changed traditional views of schizophrenia. British Journal of Psychiatry Bulletin
41: 124–125.
McGuffin
P
,
Gottesman
II
and
Owen
MJ
(2002) Psychiatric Genetics and Genomics. New York, NY: Oxford University Press.
Moises
HW
and
Gottesman
II
(2000) Genetics, risk factors and personality factors. In:
Henn
F
,
Sartorius
H
,
Helmchen
H
and
Lauter
N
(eds) Contemporary Psychiatry, vol. 3, pp. 47–59. Heidelberg/New York, NY: Springer.
Ritsner
MS
(2011) Handbook of Schizophrenia Spectrum Disorders. Heidelberg: Springer.
Sullivan
PF
,
Kendler
KS
and
Neale
MC
(2003) Schizophrenia as a complex trait: evidence from meta‐analysis of twin studies. Archives of General Psychiatry
60: 1187–1192.
Sullivan
PF
,
Agrawal
A
,
Bulik
CM
, et al. (2018) Psychiatric genomics: an update and an agenda. American Journal of Psychiatry
175: 15–27.
Weinberger
DR
(2017) Future of days past: neurodevelopment and schizophrenia. Schizophrenia Bulletin
43: 1164–1168.
Weinberger
DR
and
Harrison
P
(2011) Schizophrenia, 3rd edn.
Chichester: Wiley‐Blackwell.
Yildiz
A
,
Ruiz
P
and
Nemeroff
C
(2015)
The Bipolar Book – History, Neurobiology, and Treatment
. Oxford: Oxford University Press.