Ectopic Transcription
Lutz‐Peter Berg, Science and Technology Office, Embassy of Switzerland, London, UK
Published online: September 2005
DOI: 10.1038/npg.els.0005285
Abstract
Ectopic (or illegitimate) transcription is the very low level of transcription of ‘tissue‐specific’ genes in cell types lacking
obvious requirement for the gene product. Thought to be produced by every gene in every cell type, ectopic transcripts isolated
from patient blood are useful for gene mutation studies if the main expressing tissue of a disease gene is inaccessible.
Keywords: transcription; tissue‐specific; RT‐PCR; mutation; splicing
References
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Illegitimate transcription: its use in the study of inherited disease.
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1: 357–360.
Web Links
Coagulation factor VIII, procoagulant component (hemophilia A) (F8); Locus ID: 2157. LocusLink:
http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2157
Dystrophin (muscular dystrophy, Duchenne and Becker types) (DMD); Locus ID: 1756. LocusLink:
http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1756
Coagulation factor VIII, procoagulant component (hemophilia A) (F8); MIM number: 306700. OMIM:
http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?306700
Dystrophin (muscular dystrophy, Duchenne and Becker types) (DMD); MIM number 310200. OMIM: http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?310200