Lisabeth F DiLalla, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
Rebecca Caraway, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
Published online: July 2006
DOI: 10.1038/npg.els.0005293
Psychopathology, or mental illness, can be studied developmentally by examining changes in the illness over time as well as childhood predictors of illness. Longitudinal family studies have yielded information about childhood predictors of schizophrenia and mood disorders by identifying high-risk children of mentally ill parents prior to the diagnosis of illness in the children.
Keywords: schizophrenia; mood disorders; family studies; psychopathology; high-risk children
| References | |
| Amminger GP, Pape S, Rock D, et al. (2000) The New York High-Risk Project: comorbidity for axis I disorders is preceded by childhood behavioral disturbances. Journal of Nervous and Mental Disease 188: 751–756. | |
| Cannon TD, Mednick SA, Parnas J and Schulsinger F (1993) Developmental brain abnormalities in the offspring of schizophrenic mothers: I. Contributions of genetic and prenatal factors. Archives of General Psychiatry 50: 551–564. | |
| Erlenmeyer-Kimling L, Rock D, Roberts SA, et al. (2000) The New York High-Risk Project: attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses. American Journal of Psychiatry 157: 1416–1422. | |
| book Gottesman II (1991) Schizophrenia Genesis: The Origins of Madness, 5th edn. New York, NY: WH Freeman. | |
| Hammen C, Burge D, Burney E and Adrian C (1990) Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder. Archives of General Psychiatry 47: 1112–1117. | |
| Hammen C, Burge D, Burney E and Adrian C (1991) Timing of mother and child depression in a longitudinal study of children at risk. Journal of Consulting and Clinical Psychology 59: 341–345. | |
| Ingraham LJ, Kugelmass S, Frenkel E, Nathan M and Mirsky AF (1995) Twenty-five-year follow-up of the Israeli High-Risk Study: current and lifetime psychopathology. Schizophrenia Bulletin 21: 183–192. | |
| Olin SS, Mednick SA, Cannon TD, et al. (1998) School teachers' ratings predictive of psychiatric outcome 25 years later. British Journal of Psychiatry 172: 7–13. | |
| Parnas J, Cannon TD, Jacobsen B, et al. (1993) Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Archives of General Psychiatry 50: 707–714. | |
| book Plomin R, De Fries JC, McClearn GE and Rutter M (1997) Behavioral Genetics, 3rd edn. New York, NY: WH Freeman. | |
| Price RA, Kidd KK and Weissman MM (1987) Early onset (under age 30 years) and panic disorder as markers for etiological homogeneity in major depression. Archives of General Psychiatry 44: 434–440. | |
| Sohlberg SC (1985) Personality and neuropsychological performance of high-risk children. Schizophrenia Bulletin 11: 48–60. | |
| Weissman MM, Warner V, Wickramarante P, Moreau D and Olfson M (1997) Offspring of depressed parents. Archives of General Psychiatry 54: 932–940. | |
| Further Reading | |
| Erlenmeyer-Kimling L, Adamo UH, Rock D, et al. (1997) The New York High-Risk Project: prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at age 25-year follow-up. Archives of General Psychiatry 54: 1096–1102. | |
| Erlenmeyer-Kimling L, Squires-Wheeler E, Adamo UH, et al. (1995) The New York High-Risk Project: psychoses and cluster A personality disorders in offspring of schizophrenic parents at 23-year follow-up. Archives of General Psychiatry 52: 857–865. | |
| book Gottesman II and Shields J (with the assistance of Hanson DR) (1982) Schizophrenia: The Epigenetic Puzzle. New York, NY: Cambridge University Press. | |
| Mednick SA, Parnas J and Schulsinger F (1987) The Copenhagen High-Risk Project, 1962–86. Schizophrenia Bulletin 13: 485–495. | |
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