Restriction Fragment Length Polymorphism (RFLP)

Paul H Dear, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Published online: September 2005

DOI: 10.1038/npg.els.0005358

A restriction fragment length polymorphism is a fragment produced by restriction enzyme digestion of genomic deoxyribonucleic acid, whose length is variable because of a sequence polymorphism that affects the presence or location of a target site for the stated restriction enzyme.

Keywords: genome map; genetic linkage map; polymorphism; marker; restriction enzyme; physical mapping

Related Sub-Topics:

Replication and Recombination | Techniques and Tools in Clinical Genetics | Linkage Analysis | Inter-Individual Variation and Polymorphism | Techniques and Tools in Molecular Biology
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Article Title: Restriction Fragment Length Polymorphism (RFLP)
 
How to Cite close
Dear, Paul H(Sep 2005) Restriction Fragment Length Polymorphism (RFLP). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005358]