Genetic Linkage Mapping


Random occurrences of crossovers along a chromosome permit definition of a genetic distance. Such distances are used to create genetic maps and to localize disease genes on these maps.

Keywords: recombination; crossover; chiasma; genetic marker; disease gene

Figure 1.

Effects of a crossover between two loci on resulting gametes (right‐hand side) and corresponding genetic phenotypes (left side), where R=recombinant and N=nonrecombinant gamete.



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Further Reading

Strachan T and Read AP (1996) Human Molecular Genetics. New York, NY: Wiley‐Liss.

Sturtevant AH (2001) A History of Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

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Hoh, Josephine, and Ott, Jurg(Sep 2005) Genetic Linkage Mapping. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005360]