Genetic Linkage Mapping

Josephine Hoh, Rockefeller University, New York, USA
Jurg Ott, Rockefeller University, New York, USA

Published online: September 2005

DOI: 10.1038/npg.els.0005360

Random occurrences of crossovers along a chromosome permit definition of a genetic distance. Such distances are used to create genetic maps and to localize disease genes on these maps.

Keywords: recombination; crossover; chiasma; genetic marker; disease gene

Figure 1. Effects of a crossover between two loci on resulting gametes (right-hand side) and corresponding genetic phenotypes (left side), where R=recombinant and N=nonrecombinant gamete.
close
 References
    Botstein D, White RL, Skolnick MH and Davies RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics 32: 314–331.
    Collins A, Frézal J, Teague J and Morton NE (1996) A metric map of humans: 23500 loci in 850 bands. Proceedings of the National Academy of Sciences of the United States of America 93: 14771–14775.
    Dausset J, Cann H, Cohen D, et al. (1990) Centre d'Etude du Polymorphisme Humain (CEPH): collaborative genetic mapping of the human genome. Genomics 6: 575–577.
    Gordon D, Heath SC and Ott J (1999) True pedigree errors more frequent than apparent errors for single nucleotide polymorphisms. Human Heredity 49: 65–70.
    Gordon D and Ott J (2001) Assessment and management of single nucleotide polymorphism genotype errors in genetic association analysis. Pacific Symposia in Biocomputing 2001: 18–29.
    Hoh J, Wille A and Ott J (2001) Trimming, weighting, and grouping SNPs in human case–control association studies. Genome Research 11: 2115–2119.
    Kruglyak L (1997) The use of a genetic map of biallelic markers in linkage studies. Nature Genetics 17: 21–24.
    Lander ES, Green P, Abrahamson J, et al. (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174–181.
    Mendel G (1866) Versuche über Pflanzen-Hybriden. Verhandlungen des Naturforschenden Vereines Brünn 4: 3–47.
    book Ott J (1999) Analysis of Human Genetic Linkage. Baltimore, MD: Johns Hopkins University Press.
    Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 98: 503–517.
    book Strickberger MW (1985) Genetics, 3rd edn. New York, NY: Macmillan.
    Sturtevant AH (1913) The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. Journal of Experimental Zoology 14: 43–59.
    Terwilliger JD, Ding Y and Ott J (1992) On the relative importance of marker heterozygosity and intermarker distance in gene mapping. Genomics 13: 951–956.
 Further Reading
    book Strachan T and Read AP (1996) Human Molecular Genetics. New York, NY: Wiley-Liss.
    book Sturtevant AH (2001) A History of Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

Related Sub-Topics:

Techniques and Tools in Clinical Genetics | Linkage Analysis | Statistical Methodology in Genetics | Gene Mapping by Disease Association | Techniques and Tools in Molecular Biology
Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

Article Title: Genetic Linkage Mapping
 
How to Cite close
Hoh, Josephine, and Ott, Jurg(Sep 2005) Genetic Linkage Mapping. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005360]