Insulin‐dependent Diabetes Mellitus (IDDM): Identifying the Disease‐causing Gene at the IDDM11 Locus


In complex diseases, genome linkage analysis, fine mapping and association studies are used to identify disease‐causing genes. With the completion of the human genome sequence and its annotation, positional candidate gene studies have become an attractive method to identify genes involved in complex disorders by screening for selected chromosomal interval regions.

Keywords: diabetes; locus; genes; linkage; insulin‐dependent diabetes mellitus


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Pociot F, Larsen ZM, Zavattari P, et al. (2001) No evidence for SEL1L as a candidate gene for IDDM11‐conferred susceptibility. Diabetes/Metabolism Research and Reviews 17: 292–295.

Further Reading

Field LL (2002) Genetic linkage and association studies of type 1 diabetes: challenges and rewards. Diabetologia 45: 21–35.

Jensen J, Pedersen EE, Galante P, et al. (2000) Control of endodermal endocrine development by Hes‐1. Nature Genetics 24: 36–44.

Pociot F and McDermott MF (2002) Genetics of type 1 diabetes mellitus. Genes and Immunity 3: 235–249.

Risch N, Ghosh S and Todd JA (1993) Statistical evaluation of multiple‐locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin‐dependent diabetes mellitus (IDDM). American Journal of Human Genetics 53: 702–714.

Tabor HK, Risch NJ and Myers RM (2002) Candidate‐gene approaches for studying complex genetic traits: practical considerations. Nature Reviews Genetics 3: 1–7.

Wass J and Shalet S (eds.) (2002) Oxford Textbook of Endocrinology and Diabetes Oxford, UK: Oxford University Press.

Web Links

HUGO Gene Nomenclature Committee (HGNC)

OMIM (Online Mendelian Inheritance in Man)

Sanger Centre (The MHC haplotype Project)

IDDM2 (insulin‐dependent diabetes mellitus 2); LocusID: 3401. LocusLink:

IDDM11 (insulin‐dependent diabetes mellitus 11); LocusID: 3410. LocusLink:

SEL1L (sel‐1 suppressor of lin‐12‐like (C. elegans)); LocusID: 6400. LocusLink:

IDDM2 (insulin‐dependent diabetes mellitus 2); MIM number: 125852. OMIM:‐post/Omim/dispmim?125852

IDDM11 (insulin‐dependent diabetes mellitus 11); MIM number: 601208. OMIM:‐post/Omim/dispmim?601208

SEL1L (sel‐1 suppressor of lin‐12‐like(C. elegans)); MIM number: 602329. OMIM:‐post/Omim/dispmim?602329

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Zollo, Massimo, Dear, Paul, and Pociot, Flemming(Sep 2005) Insulin‐dependent Diabetes Mellitus (IDDM): Identifying the Disease‐causing Gene at the IDDM11 Locus. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005377]