Linkage Analysis

Abstract

Linkage analysis is the study of the association of inheritance of chromosome parts with phenotype in pedigrees.

Keywords: linkage; segregation; mapping; genetic model power; complex genetic disease; Mendelian

References

Barnard GA (1949) Statistical inference. Journal of the Royal Statistical Society B11: 115–139.

Davies and White M (1995) Breakthrough: The Race to Find the Breast Cancer Gene. London, UK: Macmillan.

Hodge SE, Abreu PC and Greenberg DA (1997) Magnitude of type I error when single‐locus linkage analysis is maximized over models: a simulation study. American Journal of Human Genetics 60(1): 217–227.

Houwen R, Baharloo S, Sandkuijl LA, et al. (1994) Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nature Genetics 8: 380–386.

Leegwater PAJ, Vermeulen G, Könst AAM, et al. (2001) Subunits of the translation initiation factor eIF2B are mutated in leukoencephalopathy with vanishing white matter. Nature Genetics 29: 383–388.

MacLean CJ, Bishop DT, Sherman SL, et al. (1993) Distribution of lod scores under uncertain mode of inheritance. American Journal of Human Genetics 52(2): 354–361.

Morton NE (1955) Sequential tests for the detection of linkage. American Journal of Human Genetics 7: 277–318.

Pritchard JK (2001) Are rare variants responsible for susceptibility to complex diseases? American Journal of Human Genetics 69: 124–137.

Sawcer S, Jones HB, Keakes R, et al. (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genetics 13: 464–468.

Further Reading

Clerget‐Darpoux F, Bonaiti‐Pellie C and Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42: 393–400.

Elston RC, Buxbaum S, Jacobs KB and Olson JM (2000) Haseman and Elston revisited. Genetic Epidemiology 19: 1–17.

Elston RC and Stewart J (1971) A general model for analysis of pedigree data. Human Heredity 21: 523–542.

Haines JL, Ter‐Minassian M, Bazyk A, et al. (1996) A complete genomic screen for multiple sclerosis under‐scores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nature Genetics 13: 469–471.

Hillert J (2000) MS genetics: recent Scandinavian efforts. Journal of NeuroVirology 6(supplement 2): S15–S17.

Lander E and Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241–247.

Ott J (1976) A computer program for linkage analysis of general human pedigrees. American Journal of Human Genetics 28: 528–529.

Nezer C, Moreau L, Wagenaar D and Georges M (2002). Results of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain x Large White intercross. Genetics, Selection, Evolution 34(3): 371–387.

Pritchard JK, Stephens M, Rosenberg NA and Donnelly P (2000) Association mapping in structured populations. American Journal of Human Genetics 67: 170–181.

Risch N and Botstein D (1996) A manic‐depressive history. Nature Genetics 12: 351–353.

Risch N and Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273(5281): 1516–1517.

Tienari PJ, Wikstrom J, Koskimies S, et al. (1993) Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families. European Journal of Human Genetics 1: 257–268.

Xu C, Dai Y, Fredrikson S and Hillert J (1999) Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23. European Journal of Human Genetics 7: 110–116.

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Meerman, GJ te(Jan 2006) Linkage Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005397]