Linkage analysis is the study of the association of inheritance of chromosome parts with phenotype in pedigrees.
Keywords: linkage; segregation; mapping; genetic model power; complex genetic disease; Mendelian
Linkage Analysis
GJ te Meerman, University of Groningen, Groningen, The Netherlands
Published online: January 2006
DOI: 10.1038/npg.els.0005397
| References | |
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| Further Reading | |
| Clerget-Darpoux F, Bonaiti-Pellie C and Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42: 393–400. | |
| Elston RC, Buxbaum S, Jacobs KB and Olson JM (2000) Haseman and Elston revisited. Genetic Epidemiology 19: 1–17. | |
| Elston RC and Stewart J (1971) A general model for analysis of pedigree data. Human Heredity 21: 523–542. | |
| Haines JL, Ter-Minassian M, Bazyk A, et al. (1996) A complete genomic screen for multiple sclerosis under-scores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nature Genetics 13: 469–471. | |
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| Lander E and Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241–247. | |
| Ott J (1976) A computer program for linkage analysis of general human pedigrees. American Journal of Human Genetics 28: 528–529. | |
| Nezer C, Moreau L, Wagenaar D and Georges M (2002). Results of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain x Large White intercross. Genetics, Selection, Evolution 34(3): 371–387. | |
| Pritchard JK, Stephens M, Rosenberg NA and Donnelly P (2000) Association mapping in structured populations. American Journal of Human Genetics 67: 170–181. | |
| Risch N and Botstein D (1996) A manic-depressive history. Nature Genetics 12: 351–353. | |
| Risch N and Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273(5281): 1516–1517. | |
| Tienari PJ, Wikstrom J, Koskimies S, et al. (1993) Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families. European Journal of Human Genetics 1: 257–268. | |
| Xu C, Dai Y, Fredrikson S and Hillert J (1999) Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23. European Journal of Human Genetics 7: 110–116. | |
