Genetic Distance and Mapping Functions

Abstract

While distances between genetic loci are generally measured in four different ways, genetic mapping is specifically based on a distance measure that expresses the probability of observing a recombination in the interval between two marker loci. A map function describes the mathematical relationship between the recombination fraction and the genetic map distance.

Keywords: base; Haldane; Kosambi; Morgan; recombination fraction

Figure 1.

The conversion from map distance (in morgans) to recombination fractions with map functions by Haldane, Kosambi and Morgan.

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References

Haldane JBS (1919) The combination of linkage values and the calculation of distances between the loci of linked factors. Journal of Genetics 8: 299–309.

Kosambi DD (1944) The estimation of map distances from recombination values. Annals of Eugenics 12: 172–175.

Liberman U and Karlin S (1984) Theoretical models of genetic map functions. Theoretical Population Biology 25: 331–346.

Morgan TH (1911) Random segregation versus coupling in Mendelian inheritance. Science 34: 384.

Strachan T and Read AP (1999) Human Molecular Genetics 2. New York, NY: John Wiley.

Further Reading

Broman KW and Weber JL (2000) Characterization of human crossover interference. American Journal of Human Genetics 66: 1911–1926.

Ott J (2000) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press.

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How to Cite close
Ziegler, Andreas, and König, Inke R(Jan 2006) Genetic Distance and Mapping Functions. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005399]