Andreas Ziegler, Medical University of Lübeck, Lübeck, Germany
Inke R König, Medical University of Lübeck, Lübeck, Germany
Published online: January 2006
DOI: 10.1038/npg.els.0005399
While distances between genetic loci are generally measured in four different ways, genetic mapping is specifically based on a distance measure that expresses the probability of observing a recombination in the interval between two marker loci. A map function describes the mathematical relationship between the recombination fraction and the genetic map distance.
Keywords: base; Haldane; Kosambi; Morgan; recombination fraction
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Figure 1. The conversion from map distance (in morgans) to recombination fractions with map functions by Haldane, Kosambi and Morgan.
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| References | |
| Haldane JBS (1919) The combination of linkage values and the calculation of distances between the loci of linked factors. Journal of Genetics 8: 299–309. | |
| Kosambi DD (1944) The estimation of map distances from recombination values. Annals of Eugenics 12: 172–175. | |
| Liberman U and Karlin S (1984) Theoretical models of genetic map functions. Theoretical Population Biology 25: 331–346. | |
| Morgan TH (1911) Random segregation versus coupling in Mendelian inheritance. Science 34: 384. | |
| book Strachan T and Read AP (1999) Human Molecular Genetics 2. New York, NY: John Wiley. | |
| Further Reading | |
| Broman KW and Weber JL (2000) Characterization of human crossover interference. American Journal of Human Genetics 66: 1911–1926. | |
| book Ott J (2000) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press. | |
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