Genetic Distance and Mapping Functions


While distances between genetic loci are generally measured in four different ways, genetic mapping is specifically based on a distance measure that expresses the probability of observing a recombination in the interval between two marker loci. A map function describes the mathematical relationship between the recombination fraction and the genetic map distance.

Keywords: base; Haldane; Kosambi; Morgan; recombination fraction

Figure 1.

The conversion from map distance (in morgans) to recombination fractions with map functions by Haldane, Kosambi and Morgan.



Haldane JBS (1919) The combination of linkage values and the calculation of distances between the loci of linked factors. Journal of Genetics 8: 299–309.

Kosambi DD (1944) The estimation of map distances from recombination values. Annals of Eugenics 12: 172–175.

Liberman U and Karlin S (1984) Theoretical models of genetic map functions. Theoretical Population Biology 25: 331–346.

Morgan TH (1911) Random segregation versus coupling in Mendelian inheritance. Science 34: 384.

Strachan T and Read AP (1999) Human Molecular Genetics 2. New York, NY: John Wiley.

Further Reading

Broman KW and Weber JL (2000) Characterization of human crossover interference. American Journal of Human Genetics 66: 1911–1926.

Ott J (2000) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press.

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Ziegler, Andreas, and König, Inke R(Jan 2006) Genetic Distance and Mapping Functions. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005399]