Lod scores are test statistics based on likelihood ratios. They are used to detect genetic linkage.
Keywords: linkage detection; sequential test; significance levels; multilocus analysis; recombination frequencies
Lod Score
Elizabeth A Thompson, University of Washington, Seattle, Washington, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005400
| References | |
| Barnard GA (1949) Statistical inference. Journal of the Royal Statistical Society Series B 11: 115–139. | |
| Edwards JH (1976) The interpretation of lod scores in linkage analysis. Human Gene Mapping 3: 289–293. | |
| Haldane JBS and Smith CAB (1947) A new estimate of the linkage between the genes for colour-blindness and haemophilia in man. Annals of Eugenics 14: 10–31. | |
| Lander ES and Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241–247. | |
| Lathrop GM, Lalouel JM, Julier C and Ott J (1984) Strategies for multilocus linkage analysis in humans. Proceedings of the National Academy of Sciences of the United States of America 81: 3443–3446. | |
| Morton NE (1955) Sequential tests for the detection of linkage. American Journal of Human Genetics 7: 277–318. | |
| book Ott J (1999) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: The Johns Hopkins University Press. | |
| Smith CAB (1953) Detection of linkage in human genetics (With Discussion). Journal of the Royal Statistical Society, Series B, 15: 153–192. | |
| book Wald A (1947) Sequential Analysis. New York, NY: Wiley. | |
| Further Reading | |
| other A paper detailing many of the early statistical ideas concerning the detection of human genetic linkage is that of Smith (1953). A recommended modern text is Ott (1999). | |
