Courtney Gray‐McGuire, Case Western Reserve University, Cleveland, Ohio, USA
Jane M Olson, Case Western Reserve University, Cleveland, Ohio, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005402
Some linkage methods do not depend on prior specification of a model of inheritance for the trait of interest. Based on identity-by-descent allele sharing information on pairs or sets of related individuals, these methods can be used to assess linkage to both qualitative and quantitative traits.
Keywords: identity-by-descent sharing; affected sib-pairs; affected relative pairs; model-free
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| Further Reading | |
| book Elston RC and Cordell HJ (1999) "Overview of model-free methods for linkage analysis". In: Rao DC and Province MA (eds.) Genetic Dissection of Complex Traits, pp. 135–147. San Diego, CA: Academic Press | |
| book Goldgar DE (1998) "Sib pair analysis". In: Haines JL and Pericak-Vance MA (eds.) Gene-mapping in Complex Human Diseases, pp. 273–303. New York: Wiley-Liss. | |
| Lander ES and Schork NJ (1994) Genetic dissection of complex traits. Science 265: 2037–2048. | |
| book Olson JM (1998) "Linkage analysis, model-free". In: Armitage P and Colton T (eds.) The Encyclopedia of Biostatistics, pp. 2291–2301. Chichester, UK: John Wiley. | |
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