Relatives‐based Nonparametric Analysis of Linkage

Abstract

Some linkage methods do not depend on prior specification of a model of inheritance for the trait of interest. Based on identity‐by‐descent allele sharing information on pairs or sets of related individuals, these methods can be used to assess linkage to both qualitative and quantitative traits.

Keywords: identity‐by‐descent sharing; affected sib‐pairs; affected relative pairs; model‐free

References

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Further Reading

Elston RC and Cordell HJ (1999) Overview of model‐free methods for linkage analysis. In: Rao DC and Province MA (eds.) Genetic Dissection of Complex Traits, pp. 135–147. San Diego, CA: Academic Press

Goldgar DE (1998) Sib pair analysis. In: Haines JL and Pericak‐Vance MA (eds.) Gene‐mapping in Complex Human Diseases, pp. 273–303. New York: Wiley‐Liss.

Lander ES and Schork NJ (1994) Genetic dissection of complex traits. Science 265: 2037–2048.

Olson JM (1998) Linkage analysis, model‐free. In: Armitage P and Colton T (eds.) The Encyclopedia of Biostatistics, pp. 2291–2301. Chichester, UK: John Wiley.

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How to Cite close
Gray‐McGuire, Courtney, and Olson, Jane M(Jan 2006) Relatives‐based Nonparametric Analysis of Linkage. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005402]