Multilocus Linkage Analysis

Konstantin Strauch, University of Bonn, Bonn, Germany

Published online: January 2006

DOI: 10.1038/npg.els.0005404

With multilocus linkage analysis, more than two loci are simultaneously considered for linkage. When mapping a disease gene relative to a group of markers with known intermarker recombination fractions, it is possible to perform parametric (lod score) as well as nonparametric analysis.

Keywords: multipoint; interference; parametric analysis; lod score; nonparametric analysis

 References
    Abecasis GR, Cherny SS, Cookson WO and Cardon LR (2002) MERLIN – rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics 30: 97–101.
    Clerget-Darpoux F, Bonaïti-Pellié C and Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42: 393–399.
    Commenges D and Beurton-Aimar M (1999) Multipoint linkage analysis using the weighted-pairwise correlation statistic. Genetic Epidemiology 17(supplement 1): S515–S519.
    Cottingham Jr RW, Idury RM and Schäffer AA (1993) Faster sequential genetic linkage computations. American Journal of Human Genetics 53: 252–263.
    Curtis D and Sham PC (1994) Using risk calculation to implement an extended relative pair analysis. Annals of Human Genetics 58: 151–162.
    Elston RC and Stewart J (1971) A general model for the genetic analysis of pedigree data. Human Heredity 21: 523–542.
    Gudbjartsson DF, Jonasson K, Frigge ML and Kong A (2000) ALLEGRO, a new computer program for multipoint linkage analysis. Nature Genetics 25: 12–13.
    Halpern J and Whittemore AS (1999) Multipoint linkage analysis. A cautionary note. Human Heredity 49: 194–196.
    book Hinds DA and Risch N (1996) The ASPEX package: affected sib-pair exclusion mapping. ftp://lahmed.stanford.edu/pub/aspex
    Knapp M, Seuchter SA and Baur MP (1994) Linkage analysis in nuclear families. 1. Optimality criteria for affected sib-pair tests. Human Heredity 44: 37–43.
    Kong A and Cox NJ (1997) Allele-sharing models: lod scores and accurate linkage tests. American Journal of Human Genetics 61: 1179–1188.
    Kruglyak L, Daly MJ, Reeve-Daly MP and Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. American Journal of Human Genetics 58: 1347–1363.
    Kruglyak L and Lander ES (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. American Journal of Human Genetics 57: 439–454.
    Lander ES and Green P (1987) Construction of multilocus genetic linkage maps in humans. Proceedings of the National Academy of Sciences of the United States of America 84: 2363–2367.
    Lander ES, Green P, Abrahamson J, et al. (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174–181.
    Lander E and Kruglyak L (1995) Genetic dissection of complex tracts: guideliness for interpreting and reporting linkage results. Nature Genetics 11: 241–247.
    Lathrop GM, Lalouel JM, Julier C and Ott J (1984) Strategies for multilocus linkage analysis in humans. Proceedings of the National Academy of Sciences of the United States of America 81: 3443–3446.
    McPeek MS (1999) Optimal allele-sharing statistics for genetic mapping using affected relatives. Genetic Epidemiology 16: 225–249.
    Morton NE (1996) Logarithm of odds (lods) for linkage in complex inheritance. Proceedings of the National Academy of Sciences of the United States of America 93: 3471–3476.
    O'Connell JR and Weeks DE (1995) The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nature Genetics 11: 402–408.
    Risch N and Giuffra L (1992) Model misspecification and multipoint linkage analysis. Human Heredity 42: 77–92.
    Schäffer AA, Gupta SK, Shriram K and Cottingham Jr RW (1994) Avoiding recomputation in linkage analysis. Human Heredity 44: 225–237.
    Speed TP, McPeek MS and Evans SN (1992) Robustness of the no-interference model for ordering genetic markers. Proceedings of the National Academy of Sciences of the United States of America 89: 3103–3106.
    Weeks DE and Lange K (1992) A multilocus extension of the affected-pedigree-member method of linkage analysis. American Journal of Human Genetics 50: 859–868.
    Weeks DE, Lathrop GM and Ott J (1993) Multipoint mapping under genetic interferences. Human Heredity 43: 86–97.
    Whittemore AS (1996) Genome scanning for linkage: an overview. American Journal of Human Genetics 59: 704–716.
    Zhao H, Sheffield LJ, Pakstis AJ, Knauert MP and Kidd KK (1999) A more powerful method to evaluate p-values in GENEHUNTER. Genetic Epidemiology 17(supplement 1): S415–S420.
 Further Reading
    Davis S and Weeks DE (1997) Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation. American Journal of Human Genetics 61: 1431–1444.
    book Ott J (1999) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press.
    Sengul H, Weeks DE and Feingold E (2001) A survey of affected-sibship statistics for non-parametric linkage analysis. American Journal of Human Genetics 69: 179–190.
    book Strauch K (2002) Kopplungsanalyse bei genetisch komplexen Erkrankungen mit genomischem Imprinting und Zwei-Genort-Krankheitsmodellen. Munich, Germany: Urban & Vogel.
    book Terwilliger JD and Ott J (1984) Handbook of Human Genetic Linkage. Baltimore, MD: Johns Hopkins University Press.

Related Sub-Topics:

Linkage Analysis | Statistical Methodology in Genetics
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Article Title: Multilocus Linkage Analysis
 
How to Cite close
Strauch, Konstantin(Jan 2006) Multilocus Linkage Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005404]