Multilocus Linkage Analysis

Abstract

With multilocus linkage analysis, more than two loci are simultaneously considered for linkage. When mapping a disease gene relative to a group of markers with known intermarker recombination fractions, it is possible to perform parametric (lod score) as well as nonparametric analysis.

Keywords: multipoint; interference; parametric analysis; lod score; nonparametric analysis

References

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Further Reading

Davis S and Weeks DE (1997) Comparison of nonparametric statistics for detection of linkage in nuclear families: single‐marker evaluation. American Journal of Human Genetics 61: 1431–1444.

Ott J (1999) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press.

Sengul H, Weeks DE and Feingold E (2001) A survey of affected‐sibship statistics for non‐parametric linkage analysis. American Journal of Human Genetics 69: 179–190.

Strauch K (2002) Kopplungsanalyse bei genetisch komplexen Erkrankungen mit genomischem Imprinting und Zwei‐Genort‐Krankheitsmodellen. Munich, Germany: Urban & Vogel.

Terwilliger JD and Ott J (1984) Handbook of Human Genetic Linkage. Baltimore, MD: Johns Hopkins University Press.

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How to Cite close
Strauch, Konstantin(Jan 2006) Multilocus Linkage Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005404]