Quantitative Trait Loci (QTL) Mapping

Quantitative trait loci (QTL) mapping is a genome-wide inference of the relationship between genotype at various genomic locations and phenotype for a set of quantitative traits in terms of the number, genomic positions, effects and interaction of QTLs.

Keywords: quantitative tracts; quantitative trait loci; QTL mapping; linkage analysis; genetic architecture of complex trait

Figure 1. Genetic mapping of QTL on wing shape from a long-term divergent selection in chromosomes 3 and 2 of Drosophila melanogaster. Lod score curves of a multiple interval mapping analysis are shown on a linkage map of chromosomes 3 and 2 (a, b). Marker positions are denoted by triangles. See also
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 References
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    book Basten C, Weir BS and Zeng Z-B (1995–2002) QTL Cartographer. Raleigh, NC: Department of Statistics, North Carolina State University. http://statgen.ncsu.edu/qtlcart/cartographer.html
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    Jiang C and Zeng Z-B (1997) Mapping quantitative trait loci with dominant and missing markers in various crosses from two inbred lines. Genetica 101: 47–58.
    Kao C-H and Zeng Z-B (1997) General formulae for obtaining the MLEs and the asymptotic variance–covariance matrix in mapping quantitative trait loci when using the EM algorithm. Biometrics 53: 653–665.
    Kao C-H, Zeng Z-B and Teasdale R (1999) Multiple interval mapping for quantitative trait loci. Genetics 152: 1023–1216.
    Kruglyak L and Lander ES (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. American Journal of Human Genetics 57: 439–454.
    Lander ES and Botstein D (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185–199.
    Nakamichi R, Ukai Y and Kishino H (2001) Detection of closely linked multiple quantitative trait loci using a genetic algorithm. Genetics 158: 463–475.
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    Sillanpaa MJ and Arjas E (1998) Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data. Genetics 148: 1373–1388.
    book Wang S, Basten C and Zeng Z-B (1999–2002) Windows QTL Cartographer. Raleigh, NC: Department of Statistics, North Carolina State University. http://statgen.ncsu.edu/qtlcart/cartographer.html
    Weber KE (1990) Selection on wing allometry in Drosophila melanogaster. Genetics 126: 975–989.
    Weber K, Eisman R, Higgins S, et al. (2001) An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster. Genetics 159: 1045–1057.
    Weber K, Eisman R, Morey L, et al. (1999) An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster. Genetics 153: 773–786.
    Zeng Z-B (1994) Precision mapping of quantitative trait loci. Genetics 136: 1457–1468.
    Zeng Z-B, Kao C-H and Basten CJ (1999) Estimating the genetic architecture of quantitative traits. Genetical Research 74: 279–289.
 Further Reading
    book Falconer DS and Mackay TFC (1996). Introduction to Quantitative Genetics 4th edn. Harlow, UK: Longman.
    book Lynch M and Walsh B (1997) Genetics and Analysis of Quantitative Characters Sunderland, MA: Sinauer Associates.
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How to Cite close
Zeng, Zhao‐Bang(Jan 2006) Quantitative Trait Loci (QTL) Mapping. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005410]