Quantitative trait loci mapping methods are statistical methods for identifying loci associated with a quantitative phenotype.
Keywords: quantitative trait loci; statistical significance; genetics; human disease; animal models
Quantitative Trait Loci (QTL) Mapping Methods
Richard Mott, Oxford University, Oxford, UK
Published online: January 2006
DOI: 10.1038/npg.els.0005411
| Further Reading | |
| book Quantitative and Statistical Genetics: Balding DJ, Bishop M and Cannings C (eds.) (2002) Handbook of Statistical Genetics New York, NY: Wiley. | |
| book Falconer DS and Mackay TF (1996) Introduction to Quantitative Genetics Reading, MA: Addison-Wesley. | |
| book Lynch M and Walsh B (1998) Genetics and Analysis of Quantitative Traits Sunderland, MA: Sinauer. | |
| book Weir BS (1996) Genetic Data Analysis 2: Methods for Discrete Population Genetic Data. Sunderland, MA: Sinauer. | |
| Reviews on QTL Mapping: Barton NH and Keightley PD (2002) Understanding quantitative genetic variation. Nature Reviews Genetics 3: 11–21. | |
| Blangero J, Williams JT and Almasy L (2000) Quantitative trait locus mapping using human pedigrees. Human Biology 72: 35–62. | |
| Flint J and Mott R (2001) Finding the molecular basis of quantitative traits: successes and pitfalls. Nature Reviews Genetics 2(6): 437–445. | |
| Mackay TF (2001) The genetic architecture of quantitative traits. Annual Review of Genetics 35: 303–339. | |
| Web Links | |
| ePath An alphabetic list of genetic analysis software. This website contains an index and web links to a large fraction of genetic analysis software available to researchers http://linkage.rockefeller.edu/soft | |
