Quantitative Trait Loci (QTL) Mapping Methods

Abstract

Quantitative trait loci mapping methods are statistical methods for identifying loci associated with a quantitative phenotype.

Keywords: quantitative trait loci; statistical significance; genetics; human disease; animal models

Further Reading

Quantitative and Statistical Genetics: Balding DJ, Bishop M and Cannings C (eds.) (2002) Handbook of Statistical Genetics New York, NY: Wiley.

Falconer DS and Mackay TF (1996) Introduction to Quantitative Genetics Reading, MA: Addison‐Wesley.

Lynch M and Walsh B (1998) Genetics and Analysis of Quantitative Traits Sunderland, MA: Sinauer.

Weir BS (1996) Genetic Data Analysis 2: Methods for Discrete Population Genetic Data. Sunderland, MA: Sinauer.

Reviews on QTL Mapping: Barton NH and Keightley PD (2002) Understanding quantitative genetic variation. Nature Reviews Genetics 3: 11–21.

Blangero J, Williams JT and Almasy L (2000) Quantitative trait locus mapping using human pedigrees. Human Biology 72: 35–62.

Flint J and Mott R (2001) Finding the molecular basis of quantitative traits: successes and pitfalls. Nature Reviews Genetics 2(6): 437–445.

Mackay TF (2001) The genetic architecture of quantitative traits. Annual Review of Genetics 35: 303–339.

Web Links

An alphabetic list of genetic analysis software. This website contains an index and web links to a large fraction of genetic analysis software available to researchers http://linkage.rockefeller.edu/soft

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How to Cite close
Mott, Richard(Jan 2006) Quantitative Trait Loci (QTL) Mapping Methods. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005411]