Psychiatric Disorders: The Search for Genes

Nick Craddock, University of Wales College of Medicine, Heath Park, Cardiff, UK

Published online: January 2006

DOI: 10.1038/npg.els.0005418

Psychiatric disorders are a set of common complex genetic disorders in which the core features include pathological disturbances of mood, cognition and behavior. Genes have already been identified for some psychiatric disorders such as Alzheimer disease, and large-scale positional and candidate gene studies are ongoing for several others including schizophrenia, bipolar disorder, depression, alcohol abuse, autism and attention deficit hyperactivity disorder.

Keywords: psychiatry; mental disorders; behavior; psychosis

 References
    book APA (1994) Diagnostic and Statistical Manual for Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association.
    Craddock N and Jones I (1999) Genetics of bipolar disorder. Journal of Medical Genetics 36(8): 585–594.
    Craddock N and Owen MJ (1996) Modern molecular genetic approaches to psychiatric disease. British Medical Bulletin 52(2): 434–452.
    Craddock N, Dave S and Greening J (2001) Association studies of bipolar disorder. Bipolar Disorders 3: 284–298.
    Lamb JA, Moore J, Bailey A and Monaco AP (2000) Autism: recent molecular genetic advances [review]. Human Molecular Genetics 9(6): 861–868.
    Lendon CL, Ashall F and Goate AM (1997) Exploring the etiology of Alzheimer's disease using molecular genetics. Journal of the American Medical Association 277(10): 825–830.
    O'Donovan M and Owen MJ (1999) Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65: 587–592.
    Owen MJ (2000) Molecular genetic studies of schizophrenia. Brain Research. Brain Research Reviews 31: 179–186.
    Thapar A, Holmes J, Poulton K and Harrington R (1999) Genetic basis of attention deficit and hyperactivity. British Journal of Psychiatry 14: 105–111.
    book WHO (1993) The ICD10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva: World Health Organization.
 Further Reading
    Craddock N (1996) Psychiatric genetics. British Journal of Psychiatry 169: 386–392.
    Farmer A and Owen MJ (1996) Genomics: the next psychiatric revolution? British Journal of Psychiatry 169: 135–138.
    book Gelder MG, Loez-Ibor JJ and Andreasen NC (eds.) (2000) New Oxford Textbook of Psychiatry. Oxford, UK: Oxford University Press.
    McGuffin P and Martin N (1999) Behaviour and genes. British Medical Journal 319: 37–40.
    book McGuffin P, Owen MJ, O'Donovan MC and Gottesman II (2002) Psychiatric Genetics and Genomics. Oxford, UK: Oxford University Press.
    book Nuffield Council on Bioethics (1998) Mental Disorders and Genetics: The Ethical Context. London: Nuffield Council on Bioethics.
    Nestler EJ (2000) Genes and addiction. Nature Genetics 26: 277–281.
    Owen M, Cardno AG and O'Donovan MC (2000) Psychiatric genetics back to the future. Molecular Psychiatry 5: 22–31.
    book Plomin R, DeFries JC, McClearn GE and McGuffin P (2001) Behavioral Genetics: A Primer, 4th edn. New York, NY: WH Freeman.
 Web Links
    ePath Amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) (APP); Locus ID: 351. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=351
    ePath Apolipoprotein E (APOE); Locus ID: 348. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=348
    ePath Huntingtin (Huntington disease) (HD); Locus ID: 3064. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3064
    ePath Presenilin 1 (Alzheimer disease 3) (PSEN1); Locus ID: 5663. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5663
    ePath Presenilin 2 (Alzheimer disease 4) (PSEN2); Locus ID: 5664. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5664
    ePath Amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) (APP); MIM number: 104760. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?104760
    ePath Apolipoprotein E (APOE); MIM number: 107741. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?107741
    ePath Huntingtin (Huntington disease) (HD); MIM number: 143100. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?143100
    ePath Presenilin 1 (Alzheimer disease 3) (PSEN1); MIM number: 104311. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?104311
    ePath Presenilin 2 (Alzheimer disease 4) (PSEN2); MIM number: 600759. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?600759

Related Sub-Topics:

Neurobiology of Disease | Molecular Genetics of Common and Complex Disease | Linkage Analysis
Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

Article Title: Psychiatric Disorders: The Search for Genes
 
How to Cite close
Craddock, Nick(Jan 2006) Psychiatric Disorders: The Search for Genes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005418]