Segregation analysis software is used to test modes of inheritance and to provide parameter estimates for genetic models.
Keywords: mode of inheritance; Elston–Stewart algorithm; likelihood; oligogenic model
Segregation Analysis Software
Christian Stricker, Applied Genetics Network, Altendorf, Switzerland
Rohan L Fernando, Iowa State University, Ames, Iowa, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005424
| References | |
| Bonney GE (1984) On the statistical determination of major gene mechanisms in continuous human traits: regressive models. American Journal of Medical Genetics 18: 731–749. | |
| Bonney GE (1986) Regressive logistic models for familial disease and other binary traits. Biometrics 42: 611–625. | |
| Cannings C, Thompson EA and Skolnick MA (1978) Probability functions on complex pedigrees. Advances in Applied Probability 10: 26–61. | |
| book Elston RC (1981) "Segregation analysis". In: Harris H and Hirschhorn K (eds.) Advances in Human Genetics, vol.II, pp. 63–120. New York, NY: Plenum Publishing. | |
| Elston RC and Stewart J (1971) A general model for the analysis of pedigree data. Human Heredity 21: 523–542. | |
| Hasstedt SJ (1991) A variance components/major locus likelihood approximation on quantitative data. Genetic Epidemiology 8: 113–125. | |
| Lander ES and Green P (1987) construction of multilocus genetic maps in humans, Proceedings of the National Academy of Sciences of the United States of America 84: 2363–2367. | |
| book Ott J (1999) Analysis of Human Genetic Linkage, 3rd edn. Baltimore, MD: Johns Hopkins University Press. | |
| Further Reading | |
| Morton NE and McLean CJ (1974) Analysis of family resemblence III. Complex segregation analysis of quantitative traits. American Journal of Human Genetics 26: 489–503. | |
| Web Links | |
| ePath Laboratory of Statistical Genetics at Rockefeller University. Web resources of genetic linkage analysis http://linkage.rockefeller.edu | |
| ePath HGAR: the Human Genetic Analysis Resource (SAGE home page) http://darwin.cwru.edu/octane/sage/sage.php | |
| ePath PAP, revision 5 http://hasstedt.genetics.utah.edu | |
| ePath Mendel 4.1.1 http://www.genetics.ucla.edu/software/ | |
