Relatives‐based Test for Linkage Disequilibrium: The Transmission/Disequilibrium Test (TDT)

Abstract

Genes that contribute to complex genetic diseases can sometimes be identified by studies that show genetic linkage, or association, with marker genes. The transmission/disequilibrium test is a procedure that tests for the simultaneous presence of these two genetic phenomena.

Keywords: linkage disequilibrium; linkage; association; transmission/ disequilibrium test; family‐based tests

References

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Further Reading

Curtis D and Sham PC (1995) A note on the application of the transmission disequilibrium test when a parent is missing. American Journal of Human Genetics 56: 811–812.

Elston RC (1998) Linkage and association. Genetic Epidemiology 15: 565–576.

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Rabinowitz D (1997) A transmission disequilibrium test for quantitative trait loci. Human Heredity 47: 342–350.

Spielman RS and Ewens WJ (1996) The TDT and other family‐based tests for linkage disequilibrium and association. American Journal of Human Genetics 59: 983–989.

Thomson G (1995) Mapping disease genes: family‐based association studies. American Journal of Human Genetics 57: 487–498.

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How to Cite close
Spielman, Richard S, and Ewens, Warren J(Jul 2006) Relatives‐based Test for Linkage Disequilibrium: The Transmission/Disequilibrium Test (TDT). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005429]