Richard S Spielman, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Warren J Ewens, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Published online: July 2006
DOI: 10.1038/npg.els.0005429
Genes that contribute to complex genetic diseases can sometimes be identified by studies that show genetic linkage, or association, with marker genes. The transmission/disequilibrium test is a procedure that tests for the simultaneous presence of these two genetic phenomena.
Keywords: linkage disequilibrium; linkage; association; transmission/ disequilibrium test; family-based tests
| References | |
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| Spielman RS and Ewens WJ (1998) A sibship test for linkage in the presence of association: the sib-transmission/disequilibrium test. American Journal of Human Genetics 62: 450–458. | |
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| Further Reading | |
| Curtis D and Sham PC (1995) A note on the application of the transmission disequilibrium test when a parent is missing. American Journal of Human Genetics 56: 811–812. | |
| Elston RC (1998) Linkage and association. Genetic Epidemiology 15: 565–576. | |
| Martin ER, Kaplan NL and Weir BS (1997) Tests for linkage and association in nuclear families. American Journal of Human Genetics 61: 439–448. | |
| Rabinowitz D (1997) A transmission disequilibrium test for quantitative trait loci. Human Heredity 47: 342–350. | |
| Spielman RS and Ewens WJ (1996) The TDT and other family-based tests for linkage disequilibrium and association. American Journal of Human Genetics 59: 983–989. | |
| Thomson G (1995) Mapping disease genes: family-based association studies. American Journal of Human Genetics 57: 487–498. | |
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