Cornelia M van Duijn, Erasmus Medical Center, Rotterdam, The Netherlands
Published online: January 2006
DOI: 10.1038/npg.els.0005430
The developments of the Human Genome Project have fueled expectations with regard to the potential of associating variations in genes to the risk of common complex diseases. Despite the many problems encountered, the examples of the HLA complex and the apolipoprotein E gene show the usefulness of this approach.
Keywords: association; human leukocyte antigen; apolipoprotein E; disease; polymorphism; complex diseases; genetic epidemiology
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| Further Reading | |
| Altshuler D, Daly M and Kruglyak L (2000) Guilt by association. Nature Genetics 26(2): 163–175. | |
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| Khoury MJ, McCabe LL and McCabe ER (2003) Population screening in the age of genomic medicine. New England Journal of Medicine 348(1): 50–58. | |
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| Web Links | |
| ePath Apolipoprotein E (APOE ); LocusID: 348. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=348 | |
| ePath Apolipoprotein E (APOE); MIM number: 107741. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?107741 | |
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