Disease Associations: Human Leukocyte Antigen (HLA) and Apolipoprotein E (APOE) Gene


The developments of the Human Genome Project have fueled expectations with regard to the potential of associating variations in genes to the risk of common complex diseases. Despite the many problems encountered, the examples of the HLA complex and the apolipoprotein E gene show the usefulness of this approach.

Keywords: association; human leukocyte antigen; apolipoprotein E; disease; polymorphism; complex diseases; genetic epidemiology


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Web Links

Apolipoprotein E (APOE ); LocusID: 348. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=348

Apolipoprotein E (APOE); MIM number: 107741. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?107741

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van Duijn, Cornelia M(Jan 2006) Disease Associations: Human Leukocyte Antigen (HLA) and Apolipoprotein E (APOE) Gene. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005430]