Mutation rate is the probability that a mutation occurs on a defined piece of genetic material over a given time frame.
Keywords: mutation rate; incidence; mutation–selection equilibrium; molecular clock
Mutation Rate
Bertram Müller‐Myhsok, Max‐Planck‐Institute of Psychiatry, Munich, Germany
Published online: December 2007
DOI: 10.1002/9780470015902.a0005441.pub2
| References | |
| Haldane JBS (1935) The rate of spontaneous mutations of a human gene. Journal of Genetics 33: 317–326. | |
| Krawczak M, Ball EV and Cooper DM (1998) Neighboring-nucleotide effects on the rates of germ-line single-base-pair substitution in human genes. American Journal of Human Genetics 63: 474–488. | |
| Leopoldino AM and Pena SDJ (2002) The mutational spectrum of human autosomal tetranucleotide microsatellites. Human Mutation 21: 71–79. | |
| Oldenburg J, Schwaab R, Grimm T et al. (1993) Direct and indirect estimation of the sex ratio of mutation frequencies in hemophilia A. American Journal of Human Genetics 53: 1229–1238. | |
| Further Reading | |
| Lercher MJ and Hurst LD (2002) Human SNP variability and mutation rate are higher in regions of high recombination. Trends in Genetics 18: 337–340. | |
| Smith NG, Webster MT and Ellegren H (2002) Deterministic mutation rate variation in the human genome. Genome Research 12: 1350–1356. | |
| Subramanian S and Kumar S (2003) Neutral substitutions occur at a faster rate in exons than in noncoding DNA in primate genomes. Genome Research 13(5): 838–844. | |
| Sunyaev S, Kondrashov FA, Bork P and Ramensky V (2003) Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics 12: 3325–3330. | |
