Disease-related Genes: Functional Analysis

Elena I Rugarli, Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
Andrea Ballabio, Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

Published online: January 2006

DOI: 10.1038/npg.els.0005486

Functional analysis of genes involved in human diseases is a critical step in understanding disease pathogenesis. The function of a given gene can be determined either at the cellular level or at the level of a whole organism in both normal and pathological conditions. Functional analysis is achieved through integration of information derived from various experimental strategies, for example, determination of gene-expression pattern, exploitation of bioinformatic resources, and biochemical and cellular studies.

Keywords: bioinformatics; gene expression; cell transfection; two-hybrid system; animal models

Figure 1. Schematic view of strategies for functional analysis of genes.
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Related Sub-Topics:

Gene Expression Profiling of Genetic Disease | Bioinformatics and Genetic Disease
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Article Title: Disease-related Genes: Functional Analysis
 
How to Cite close
Rugarli, Elena I, and Ballabio, Andrea(Jan 2006) Disease-related Genes: Functional Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005486]