Disease‐related Genes: Functional Analysis


Functional analysis of genes involved in human diseases is a critical step in understanding disease pathogenesis. The function of a given gene can be determined either at the cellular level or at the level of a whole organism in both normal and pathological conditions. Functional analysis is achieved through integration of information derived from various experimental strategies, for example, determination of gene‐expression pattern, exploitation of bioinformatic resources, and biochemical and cellular studies.

Keywords: bioinformatics; gene expression; cell transfection; two‐hybrid system; animal models

Figure 1.

Schematic view of strategies for functional analysis of genes.



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Rugarli, Elena I, and Ballabio, Andrea(Jan 2006) Disease‐related Genes: Functional Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005486]