Mutations: Penetrance

Richard Houlston, Institute of Cancer Research, Sutton, UK

Published online: January 2006

DOI: 10.1038/npg.els.0005490

A given genotype does not necessarily lead to the same phenotype. Individuals with a specific genotype will display a range of phenotypes. The relationship between genotype and a specific phenotype is referred to as penetrance.

Keywords: phenotype

 References
    Houlston RS and Tomlinson IPM (1998) Modifier genes in humans: strategies for identification. European Journal of Human Genetics 6: 80–88.
 Further Reading
    book Lynch M and Walsh B (1998) Genetics and Analysis of Quantitative Traits, chap. 13. Sunderland, MA: Sinauer Associates.

Related Sub-Topics:

Mutational Mechanisms of Genetic Disease | Statistical Methodology in Genetics | Inter-Individual Variation and Polymorphism
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Article Title: Mutations: Penetrance
 
How to Cite close
Houlston, Richard(Jan 2006) Mutations: Penetrance. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005490]