Protein Aggregation and Human Disorders

Abstract

The deposition of insoluble proteinaceous material is a distinct pathological process associated with a broad range of disparate diseases. Modulating the self‐aggregation of the proteins that form these deposits has emerged as a major therapeutic strategy for disease treatment.

Keywords: aggregation; amyloid; prion; fibrils; polyglutamine repeat

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Further Reading

Benson MD (1993) Hereditary amyloidosis. In: Conneally PM (ed.) Molecular Basis of Neurology, 1st edn. Boston, MA: Blackwell Scientific Publications.

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Wetzel RE (1999) Amyloid, Prions and Other Protein Aggregates. New York, NY: Academic Press.

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How to Cite close
Moir, Robert D, and Tanzi, Rudolph E(Jan 2006) Protein Aggregation and Human Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005496]