Posttranslational Modification and Human Disorders

Abstract

Most proteins undergo modification involving specific cleavage of the polypeptide backbone and/or changes to the side chains. Some of these modifications result in disease or disorder; others may be used diagnostically.

Keywords: posttranslational; processing; amyloid; glycosylation; toxins

Figure 1.

Three major types of posttranslational modification. (1) Cleavage of the backbone by specific proteases (P). (2) Modifications of the side chains by the addition of a group (A) catalyzed by transferases and other enzymes (T); some of these are reversible by various hydrolases (H). (3) Nonenzymic modifications by reactive molecules, ions and radicals.

Figure 2.

Metabolism of amyloid precursor protein (APP). The location of the Aβ fragment is highlighted. (a) Action of α and γ secretases. (b) Action of β and γ secretases producing Aβ (the amyloidogenic pathway).

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Further Reading

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How to Cite close
Wisdom, G Brian(Jan 2006) Posttranslational Modification and Human Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005498]