David Burgner, University of Western Australia, Perth, Western Australia, Australia
Michael Levin, Imperial College School of Science, Technology and Medicine, London, UK
Published online: January 2006
DOI: 10.1038/npg.els.0005506
There is increasing evidence of genetic predisposition to both susceptibility and outcome in human infection. Examples from animal studies, single-gene immunological defects and polygenic disorders have identified fundamental processes in infectious diseases and are likely to revolutionize the approach to both prevention and treatment of infection.
Keywords: linkage; association; infection; susceptibility; outcome
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| Further Reading | |
| Abel L and Dessein AJ (1997) The impact of host genetics on susceptibility to human infectious diseases. Current Opinion in Immunology 9(4): 509–516. | |
| Casanova JL and Abel L (2002) Genetic dissection of immunity to mycobacteria: the Human Model. Annual Review of Immunology 20: 581–620. | |
| Cooke GS and Hill AV (2001) Genetics of susceptibility to human infectious disease. Nature Reviews Genetics 2(12): 967–977. | |
| Davenport MP and Hill AV (1996) Reverse immunogenetics: from HLA-disease associations to vaccine candidates. Molecular Medicine Today 2(1): 38–45. | |
| Fine PE (1981) Immunogenetics of susceptibility to leprosy tuberculosis and leishmaniasis. An epidemiological perspective. International Journal of Leprosy and Other Mycobacterial Diseases 49(4): 437–454. | |
| book Haldane JBS (1950) "Disease and evolution". La Ricerca Scientifica 68–75. | |
| Hill AV (1992) Malaria resistance genes: a natural selection. Transactions of the Royal Society of Tropical Medicine and Hygiene 86(3): 225–232. | |
| Kimbrell DA and Beutler B (2001) The evolution and genetics of innate immunity. Nature Reviews Genetics 2(4): 256–267. | |
| Kwiatkowski D (2000) Genetic susceptibility to malaria getting complex. Current Opinion in Genetics and Development 10(3): 320–324. | |
| Web Links | |
| ePath CCR5(chemokine(C-C motif) receptor 5); LocusID: 1234. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1234 | |
| ePath IFNGR1 (interferon gamma receptor); LocusID: 3459. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3459 | |
| ePath MBL2 (mannose-binding lectin (protein C) 2, soluble (opsonic defect)); LocusID: 4153. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4153 | |
| ePath SLC11A1 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1); LocusID: 6556. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6556 | |
| ePath http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?601373 CCR5(chemokine(C-C motif) receptor 5); 601373. OMIM: | |
| ePath http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?107470 IFNGR1(interferon gamma receptor); MIM number: 107470. OMIM: | |
| ePath http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?154545 MBL2(mannose-binding lectin(protein C) 2, soluble(opsonic defect)); MIM number: 154545. OMIM: | |
| ePath SLC11A1(solute carrier family 11(proton-coupled divalent metal ion transporters), member 1); MIM number: 600266. OMIM: http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?600266 | |
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