Infectious Diseases: Predisposition

Abstract

There is increasing evidence of genetic predisposition to both susceptibility and outcome in human infection. Examples from animal studies, single‐gene immunological defects and polygenic disorders have identified fundamental processes in infectious diseases and are likely to revolutionize the approach to both prevention and treatment of infection.

Keywords: linkage; association; infection; susceptibility; outcome

References

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Abel L and Dessein AJ (1997) The impact of host genetics on susceptibility to human infectious diseases. Current Opinion in Immunology 9(4): 509–516.

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Davenport MP and Hill AV (1996) Reverse immunogenetics: from HLA‐disease associations to vaccine candidates. Molecular Medicine Today 2(1): 38–45.

Fine PE (1981) Immunogenetics of susceptibility to leprosy tuberculosis and leishmaniasis. An epidemiological perspective. International Journal of Leprosy and Other Mycobacterial Diseases 49(4): 437–454.

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Kwiatkowski D (2000) Genetic susceptibility to malaria getting complex. Current Opinion in Genetics and Development 10(3): 320–324.

Web Links

CCR5(chemokine(C‐C motif) receptor 5); LocusID: 1234. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1234

IFNGR1 (interferon gamma receptor); LocusID: 3459. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3459

MBL2 (mannose‐binding lectin (protein C) 2, soluble (opsonic defect)); LocusID: 4153. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4153

SLC11A1 (solute carrier family 11 (proton‐coupled divalent metal ion transporters), member 1); LocusID: 6556. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6556

http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?601373 CCR5(chemokine(C‐C motif) receptor 5); 601373. OMIM:

http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?107470 IFNGR1(interferon gamma receptor); MIM number: 107470. OMIM:

http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?154545 MBL2(mannose‐binding lectin(protein C) 2, soluble(opsonic defect)); MIM number: 154545. OMIM:

SLC11A1(solute carrier family 11(proton‐coupled divalent metal ion transporters), member 1); MIM number: 600266. OMIM: http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600266

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How to Cite close
Burgner, David, and Levin, Michael(Jan 2006) Infectious Diseases: Predisposition. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005506]