Development: Disorders

Abstract

Development is the process leading to completely differentiated tissues an organs derived from a single fertilized egg. Many advances have been made toward understanding the molecular and biological basis of the cellular events involved in normal development, which allow us to foresee the classification of genetic and acquired disorders of development.

Keywords: development; organogenesis; brain development; homeotic genes; cell migration

References

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Further Reading

Boncinelli E, Mallamaci A and Broccoli V (1998) Body plan genes and human malformation. Advances in Genetics 38: 1–29.

McGinnis W and Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283–302.

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Web Links

Empty spiracles homolog 2 (Drosophila) (EMX2); Locus ID: 2018. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2018

Orthodenticle homolog 1 (Drosophila) (OTX1); Locus ID: 5013. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5013

Paired box gene 2 (PAX2); Locus ID: 5076. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5076

Sonic hedgehog homolog (Drosophila) (SHH); Locus ID: 6469. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6469

TGFB‐induced factor (TALE family homeobox) (TGIF); Locus ID: 7050. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7050

Empty spiracles homolog 2 (Drosophila) (EMX2); MIM number: 600035. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600035

Orthodenticle homolog 1 (Drosophila) (OTX1); MIM number: 600036. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600036

Paired box gene 2 (PAX2); MIM number: 167409. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?167409

Sonic hedgehog homolog (Drosophila) (SHH); MIM number: 600725. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600725

TGFB‐induced factor (TALE family homeobox) (TGIF); MIM number: 602630. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?602630

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How to Cite close
Carrozzo, Romeo, and Boncinelli, Edoardo(Jan 2006) Development: Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005507]