Trisomy

Abstract

Human trisomy is a leading cause of fetal wastage, perinatal and infant mortality, congenital malformation and mental retardation.

Keywords: trisomy; meiosis; maternal age; syndromes

References

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Further Reading

De Grouchy J and Turleau C (1984) Clinical Atlas of Human Chromosomes, 2nd edn. New York, NY: John Wiley.

Dellarco VL, Voyteck PE and Hollaender A (1985) Aneuploidy: Etiology and Mechanisms. New York, NY: Plenum Press.

Epstein CJ (1986) The Consequences of Chromosome Imbalance – Principles, Mechanisms, and Models. Cambridge, UK: Cambridge University Press.

Hook EB (1992) Chromosome abnormalities: prevalence, risks and recurrence. In: Brock DJH, Rodeck CH and Ferguson‐Smith MA (eds.) Prenatal Diagnosis and Screening, pp. 351–392. Edinburg/London, UK: Churchill Livingstone.

Schinzel A (2001) Catalogue of Unbalanced Chromosome Aberrations in Man. Berlin: Walter de Gruyter.

Shapiro BL (1983) Down syndrome – a disruption of homeostasis. American Journal of Medical Genetics 14: 241–269.

Warburton D (1989) The effect of maternal age on the frequency of trisomy: change in meiosis or in utero selection? In: Terry J. Hassold and Charles J. Epstein (eds.) Molecular and Cytogenetics Studies of Non‐Disjunction, pp. 165–186. New York, NY: Alan R Liss.

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How to Cite close
Vekemans, Michel(Jan 2006) Trisomy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005544]