Leukemias and Lymphomas: Genetics

Abstract

Leukemias and lymphomas are some of the best‐understood cancers at the molecular level. Genes involved in the pathogenesis of these diseases exemplify some of the primary mechanisms that contribute to human cancer.

Keywords: cancer; leukemia; lymphoma

References

Bergsagel PL and Kuehl WM (2001) Chromosome translocations in multiple myeloma. Oncogene 20: 5611–5622.

Chaganti RS, Nanjangud G, Schmidt H and Teruya‐Feldstein J (2000) Recurring chromosomal abnormalities in non‐Hodgkin's lymphoma: biologic and clinical significance. Seminars in Hematology 37: 396–411.

Cross NC and Reiter A (2002) Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 16: 1207–1212.

Ferrando AA and Look AT (2000) Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Seminars in Hematology 37: 381–395.

Ferrando AA, Neuberg DS, Staunton J, et al. (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1: 75–87.

Hayashi Y (2000) The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia. Seminars in Hematology 37: 368–380.

Kiyoi H and Naoe T (2002) FLT3 in human hematologic malignancies. Leukemia and Lymphoma 43: 1541–1547.

Look AT (1997) Oncogenic transcription factors in the human acute leukemias. Science 278: 1059–1064.

Look AT (2002) A leukemogenic twist for GATA1. Nature Genetics 32: 83–84.

O'Dwyer ME and Druket BJ (2000) STI571: an inhibitor of the BCR‐ABL tyrosine kinase for the treatment of chronic myelogenous leukemia. The Lancet Oncology 1: 207–211.

Pandolfi PP (2001) Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Human Molecular Genetics 10: 769–775.

Pasqualucci L, Neumeister P, Goossens T, et al. (2001) Hypermutation of multiple proto‐oncogenes in B‐cell diffuse large‐cell lymphomas. Nature 412: 341–346.

Further Reading

Bloomfield CD and Caligiury MA (2001) Molecular biology of leukemias. In: De Vita VT, Hellman S and Rosemberg SA (eds.) Cancer. Principles and Practice of Oncology, pp. 2389–2403. Philadelphia, PA: Lippincott Williams & Wilkins

Dalla‐Favera R and Gaidano G (2001) Molecular biology of lymphomas. In: De Vita VT, Hellman S and Rosemberg SA (eds.) Cancer. Principles and Practice of Oncology, pp. 2215–2234. Philadelphia, PA: Lippincott Williams & Wilkins

Gaidano G and Dalla‐Favera R (2000) Pathobiology of non‐Hodgkin lymphomas. In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 1213–1228. Philadelphia, PA: Churchill Livingstone

Le Beau MMandLarsonRA (2000) Cytogenetics and neoplasia. In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 848–869. Philadelphia, PA: Churchill Livingstone

Rubnitz JE and Look AT (2000) Pathobiology of acute lymphoblastic leukemia. In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 1052–1069. Philadelphia, PA: Churchill Livingstone

Sato Y and Rowley JD (1998) Chromosomal abnormalities in childhood hematologic malignant diseases. In: Nathan DG and Orkin SH (eds.) Hematology of Infancy and Childhood, pp. 1147–1182. Philadelphia, PA: WB Saunders Company

Stock W and Thirdman MJ (2000) Pathobiology of acute myeloid leukemia. In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 979–998. Philadelphia, PA: Churchill Livingstone

Web Links

BCR (breakpoint cluster region); Locus ID: 613. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=613

CBFA2T1 (core‐binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D‐related); Locus ID: 862. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=862

ETV6 (ets variant gene 6 (TEL oncogene)); Locus ID: 2120. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2120

MLL (myeloid/lymphoid or mixed‐lineage leukemia (trithorax homolog, Drosophila)); Locus ID: 4297. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4297

RUNX1 (runt‐related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); Locus ID: 861. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=861

BCR (breakpoint cluster region); MIM number: 151410. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?151410

CBFA2T1 (core‐binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D‐related); MIM number: 133435. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?133435

ETV6 (ets variant gene 6 (TEL oncogene)); MIM number: 600618. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600618

MLL (myeloid/lymphoid or mixed‐lineage leukemia (trithorax homolog, Drosophila)); MIM number: 159555. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?159555

RUNX1 (runt‐related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); MIM number: 151385. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?151385

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Look, A Thomas, and Ferrando, Adolfo A(Jan 2006) Leukemias and Lymphomas: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005553]