A Thomas Look, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Adolfo A Ferrando, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005553
Leukemias and lymphomas are some of the best-understood cancers at the molecular level. Genes involved in the pathogenesis of these diseases exemplify some of the primary mechanisms that contribute to human cancer.
Keywords: cancer; leukemia; lymphoma
| References | |
| Bergsagel PL and Kuehl WM (2001) Chromosome translocations in multiple myeloma. Oncogene 20: 5611–5622. | |
| Chaganti RS, Nanjangud G, Schmidt H and Teruya-Feldstein J (2000) Recurring chromosomal abnormalities in non-Hodgkin's lymphoma: biologic and clinical significance. Seminars in Hematology 37: 396–411. | |
| Cross NC and Reiter A (2002) Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 16: 1207–1212. | |
| Ferrando AA and Look AT (2000) Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Seminars in Hematology 37: 381–395. | |
| Ferrando AA, Neuberg DS, Staunton J, et al. (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1: 75–87. | |
| Hayashi Y (2000) The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia. Seminars in Hematology 37: 368–380. | |
| Kiyoi H and Naoe T (2002) FLT3 in human hematologic malignancies. Leukemia and Lymphoma 43: 1541–1547. | |
| Look AT (1997) Oncogenic transcription factors in the human acute leukemias. Science 278: 1059–1064. | |
| Look AT (2002) A leukemogenic twist for GATA1. Nature Genetics 32: 83–84. | |
| O'Dwyer ME and Druket BJ (2000) STI571: an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukemia. The Lancet Oncology 1: 207–211. | |
| Pandolfi PP (2001) Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Human Molecular Genetics 10: 769–775. | |
| Pasqualucci L, Neumeister P, Goossens T, et al. (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412: 341–346. | |
| Further Reading | |
| book Bloomfield CD and Caligiury MA (2001) "Molecular biology of leukemias". In: De Vita VT, Hellman S and Rosemberg SA (eds.) Cancer. Principles and Practice of Oncology, pp. 2389–2403. Philadelphia, PA: Lippincott Williams & Wilkins | |
| book Dalla-Favera R and Gaidano G (2001) "Molecular biology of lymphomas". In: De Vita VT, Hellman S and Rosemberg SA (eds.) Cancer. Principles and Practice of Oncology, pp. 2215–2234. Philadelphia, PA: Lippincott Williams & Wilkins | |
| book Gaidano G and Dalla-Favera R (2000) "Pathobiology of non-Hodgkin lymphomas". In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 1213–1228. Philadelphia, PA: Churchill Livingstone | |
| book Le Beau MMandLarsonRA (2000) "Cytogenetics and neoplasia". In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 848–869. Philadelphia, PA: Churchill Livingstone | |
| book Rubnitz JE and Look AT (2000) "Pathobiology of acute lymphoblastic leukemia". In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 1052–1069. Philadelphia, PA: Churchill Livingstone | |
| book Sato Y and Rowley JD (1998) "Chromosomal abnormalities in childhood hematologic malignant diseases". In: Nathan DG and Orkin SH (eds.) Hematology of Infancy and Childhood, pp. 1147–1182. Philadelphia, PA: WB Saunders Company | |
| book Stock W and Thirdman MJ (2000) "Pathobiology of acute myeloid leukemia". In: Hoffman R, Benz EJ, Shattil SJ, et al. (eds.) Hematology. Basic Principles and Practice, pp. 979–998. Philadelphia, PA: Churchill Livingstone | |
| Web Links | |
| ePath BCR (breakpoint cluster region); Locus ID: 613. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=613 | |
| ePath CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related); Locus ID: 862. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=862 | |
| ePath ETV6 (ets variant gene 6 (TEL oncogene)); Locus ID: 2120. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2120 | |
| ePath MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)); Locus ID: 4297. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4297 | |
| ePath RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); Locus ID: 861. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=861 | |
| ePath BCR (breakpoint cluster region); MIM number: 151410. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?151410 | |
| ePath CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related); MIM number: 133435. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?133435 | |
| ePath ETV6 (ets variant gene 6 (TEL oncogene)); MIM number: 600618. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?600618 | |
| ePath MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)); MIM number: 159555. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?159555 | |
| ePath RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); MIM number: 151385. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?151385 | |
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