The genetic changes in bowel cancers are particularly well defined, partly because the genetic syndromes that predispose to it are well understood.
Keywords: colon; rectum; cancer; adenoma; polyposis; HNPCC; FAP
Colorectal Cancer: Genetics
Ian M Frayling, Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, UK
Published online: January 2006
DOI: 10.1038/npg.els.0005555
| Further Reading | |
| Fodde R, Smits R and Clevers H (2001) APC, signal transduction and genetic instability in colorectal cancer. Nature Reviews Cancer 1: 55–67. | |
| Houlston RS and Tomlinson IP (2001) Polymorphisms and colorectal tumor risk. Gastroenterology 121: 282–301. | |
| Ilyas M and Tomlinson IP (1996) Genetic pathways in colorectal cancer. Histopathology 28: 389–399. | |
| Jass JR, Young J and Leggett BA (2002) Evolution of colorectal cancer: change of pace and change of direction. Journal of Gastroenterology and Hepatology 17: 17–26 (review). | |
| Leslie A, Carey FA, Pratt NR and Steele RJ (2002) The colorectal adenoma-carcinoma sequence. British Journal of Surgery 89: 845–860. | |
| Lynch HT and de la Chapelle A (1999) Genetic susceptibility to non-polyposis colorectal cancer. Journal of Medical Genetics 36: 801–818. | |
| Muller A and Fishel R (2002) Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). Cancer Investigation 20: 102–109. | |
| Potter JD (1999) Colorectal cancer: molecules and populations. Journal of the National Cancer Institute 91: 916–932. | |
| Wong NA and Pignatelli M (2002) Beta-catenin – a linchpin in colorectal carcinogenesis? American Journal of Pathology 160: 389–401. | |
| Web Links | |
| ePath Adenomatous polyposis coli (APC); Locus ID: 324. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=324 | |
| ePath Deleted in colorectal carcinoma (DCC); Locus ID: 1630. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1630 | |
| ePath MAD, mothers against decapentaplegic homolog 4 (Drosophila) (MADH4); Locus ID: 4089. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4089 | |
| ePath MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2); Locus ID: 4436. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4436 | |
| ePath MutY homolog (E. coli) (MUTYH); Locus ID: 4595. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4595 | |
| ePath Adenomatous polyposis coli (APC); MIM number: 175100. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?175100 | |
| ePath Deleted in colorectal carcinoma (DCC); MIM number: 120470. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?120470 | |
| ePath MAD, mothers against decapentaplegic homolog 4 (Drosophila) (MADH4); MIM number: 600993. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?600993 | |
| ePath MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2); MIM number: 120435. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?120435 | |
| ePath MutY homolog (E. coli) (MUTYH); MIM number: 604933. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?604933 | |
