Colorectal Cancer: Genetics


The genetic changes in bowel cancers are particularly well defined, partly because the genetic syndromes that predispose to it are well understood.

Keywords: colon; rectum; cancer; adenoma; polyposis; HNPCC; FAP

Further Reading

Fodde R, Smits R and Clevers H (2001) APC, signal transduction and genetic instability in colorectal cancer. Nature Reviews Cancer 1: 55–67.

Houlston RS and Tomlinson IP (2001) Polymorphisms and colorectal tumor risk. Gastroenterology 121: 282–301.

Ilyas M and Tomlinson IP (1996) Genetic pathways in colorectal cancer. Histopathology 28: 389–399.

Jass JR, Young J and Leggett BA (2002) Evolution of colorectal cancer: change of pace and change of direction. Journal of Gastroenterology and Hepatology 17: 17–26 (review).

Leslie A, Carey FA, Pratt NR and Steele RJ (2002) The colorectal adenoma‐carcinoma sequence. British Journal of Surgery 89: 845–860.

Lynch HT and de la Chapelle A (1999) Genetic susceptibility to non‐polyposis colorectal cancer. Journal of Medical Genetics 36: 801–818.

Muller A and Fishel R (2002) Mismatch repair and the hereditary non‐polyposis colorectal cancer syndrome (HNPCC). Cancer Investigation 20: 102–109.

Potter JD (1999) Colorectal cancer: molecules and populations. Journal of the National Cancer Institute 91: 916–932.

Wong NA and Pignatelli M (2002) Beta‐catenin – a linchpin in colorectal carcinogenesis? American Journal of Pathology 160: 389–401.

Web Links

Adenomatous polyposis coli (APC); Locus ID: 324. LocusLink:

Deleted in colorectal carcinoma (DCC); Locus ID: 1630. LocusLink:

MAD, mothers against decapentaplegic homolog 4 (Drosophila) (MADH4); Locus ID: 4089. LocusLink:

MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2); Locus ID: 4436. LocusLink:

MutY homolog (E. coli) (MUTYH); Locus ID: 4595. LocusLink:

Adenomatous polyposis coli (APC); MIM number: 175100. OMIM:‐post/Omim/dispmim?175100

Deleted in colorectal carcinoma (DCC); MIM number: 120470. OMIM:‐post/Omim/dispmim?120470

MAD, mothers against decapentaplegic homolog 4 (Drosophila) (MADH4); MIM number: 600993. OMIM:‐post/Omim/dispmim?600993

MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2); MIM number: 120435. OMIM:‐post/Omim/dispmim?120435

MutY homolog (E. coli) (MUTYH); MIM number: 604933. OMIM:‐post/Omim/dispmim?604933

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How to Cite close
Frayling, Ian M(Jan 2006) Colorectal Cancer: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005555]