Polygenic Disorders

Abstract

The vast majority of common disorders affecting humans are polygenic, due to the additive and interactive effect of multiple genes, each with a small effect, interacting with the environment. Because of their importance and frequency, polygenic disorders have a great economic impact. The identification of the genes involved promises to be significantly more difficult than the identification of the genes involved in single gene disorders.

Keywords: polygenes; linkage disequilibrium; threshold models; microsatellites; single nucleotide polymorphisms; variance

Figure 1.

Threshold model of polygenic disorders.

Figure 2.

Example of a polygenic system (see text for details).

Figure 3.

Types of linkage disequilibrium (LD) (see text for details).

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References

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How to Cite close
Comings, David E(Jan 2006) Polygenic Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005556]