Diabetes: Genetics

Paul Zimmet, International Diabetes Institute, Melbourne, Victoria, Australia
Ken Walder, Deakin University, Geelong, Victoria, Australia
Greg R Collier, Deakin University, Geelong, Victoria, Australia

Published online: January 2006

DOI: 10.1038/npg.els.0005561

Diabetes, a syndrome characterized by hyperglycemia (high blood sugar), has reached epidemic proportions in both developed and developing nations. The two forms of the disease both have a genetic basis, but are influenced by different genetic and environmental factors.

Keywords: type 1 diabetes; type 2 diabetes; insulin resistance; animal model; psammomys obesus

 Further Reading
    Collier GR, McMillan JS, Windmill K, et al. (2000) Beacon. A novel gene involved in the regulation of energy balance. Diabetes 49: 1766–1771.
    Hattersley AT (1998) Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. Diabetic Medicine 15: 15–24.
    Horikawa Y, Oda N, Cox NJ, et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genetics 26: 163–175.
    Kahn RC, Vicent D and Doria A (1996) Genetics of non-insulin-dependent (type-2) diabetes mellitus. Annual Review of Medicine 47: 509–531.
    Pedersen O (1999) Genetics of insulin resistance. Experimental and Clinical Endocrinology and Diabetes 107: 113–118.
    Shafrir E and Gutman A (1993) Psammomys obesus of the Jerusalem colony: a model for nutritionally induced, non-insulin-dependent diabetes. Journal of Basic and Clinical Physiology and Pharmacology 4: 83–99.
    Walder K, Kantham L, McMillan JS, et al. (2002) Tanis: a link between type 2 diabetes and inflammation? Diabetes 51: 1859–1866.
    book World Health Organization (1999) Report of a Consultation. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva: World Health Organization.
    Zimmet P (1999) Diabetes epidemiology as a trigger to diabetes research. Diabetologia 42: 499–518.
    Zimmet P, Alberti KGMM and Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782–787.
 Web Links
    ePath HUGO Gene Nomenclature Committee. Approved gene nomenclature and links to further information http://www.gene.ucl.ac.uk/nomenclature/
    ePath Calpain 10 (CAPN10); Locus ID: 11132. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=11132
    ePath Glucokinase (hexokinase 4, maturity onset diabetes of the young 2) (GCK); Locus ID: 2645. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2645
    ePath Calpain 10 (CAPN10); MIM number: 605286. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?605286
    ePath Glucokinase (hexokinase 4, maturity onset diabetes of the young 2) (GCK); MIM number 138079. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?138079

Related Sub-Topics:

Autoimmunity | Intracellular and Extracellular Signalling | Molecular Genetics of Common and Complex Disease | Specific Genetic Disorders
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Article Title: Diabetes: Genetics
 
How to Cite close
Zimmet, Paul, Walder, Ken, and Collier, Greg R(Jan 2006) Diabetes: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005561]