Diabetes: Genetics

Abstract

Diabetes, a syndrome characterized by hyperglycemia (high blood sugar), has reached epidemic proportions in both developed and developing nations. The two forms of the disease both have a genetic basis, but are influenced by different genetic and environmental factors.

Keywords: type 1 diabetes; type 2 diabetes; insulin resistance; animal model; psammomys obesus

Further Reading

Collier GR, McMillan JS, Windmill K, et al. (2000) Beacon. A novel gene involved in the regulation of energy balance. Diabetes 49: 1766–1771.

Hattersley AT (1998) Maturity‐onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. Diabetic Medicine 15: 15–24.

Horikawa Y, Oda N, Cox NJ, et al. (2000) Genetic variation in the gene encoding calpain‐10 is associated with type 2 diabetes mellitus. Nature Genetics 26: 163–175.

Kahn RC, Vicent D and Doria A (1996) Genetics of non‐insulin‐dependent (type‐2) diabetes mellitus. Annual Review of Medicine 47: 509–531.

Pedersen O (1999) Genetics of insulin resistance. Experimental and Clinical Endocrinology and Diabetes 107: 113–118.

Shafrir E and Gutman A (1993) Psammomys obesus of the Jerusalem colony: a model for nutritionally induced, non‐insulin‐dependent diabetes. Journal of Basic and Clinical Physiology and Pharmacology 4: 83–99.

Walder K, Kantham L, McMillan JS, et al. (2002) Tanis: a link between type 2 diabetes and inflammation? Diabetes 51: 1859–1866.

World Health Organization (1999) Report of a Consultation. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva: World Health Organization.

Zimmet P (1999) Diabetes epidemiology as a trigger to diabetes research. Diabetologia 42: 499–518.

Zimmet P, Alberti KGMM and Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782–787.

Web Links

HUGO Gene Nomenclature Committee. Approved gene nomenclature and links to further information http://www.gene.ucl.ac.uk/nomenclature/

Calpain 10 (CAPN10); Locus ID: 11132. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=11132

Glucokinase (hexokinase 4, maturity onset diabetes of the young 2) (GCK); Locus ID: 2645. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2645

Calpain 10 (CAPN10); MIM number: 605286. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?605286

Glucokinase (hexokinase 4, maturity onset diabetes of the young 2) (GCK); MIM number 138079. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?138079

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How to Cite close
Zimmet, Paul, Walder, Ken, and Collier, Greg R(Jan 2006) Diabetes: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005561]