Clinical Molecular Cytogenetics

Abstract

Molecular cytogenetics is an important tool for the diagnosis and characterization of chromosome aberrations in clinical and cancer cytogenetics.

Keywords: fluorescence in situ hybridization; comparative genomic hybridization; spectral karyotype; multiplex FISH; spectral karyotyping

Figure 1.

Diagnostic algorithm in clinical cytogenetics. CGH: comparative genomic hybridization; FISH: fluorescence in situ hybridization; HRB: high‐resolution banding; M‐FISH: multiplex‐FISH; SKY: spectral karyotyping.

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References

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Helias C, Leymarie V, Entz‐Werle N, et al. (2002) Translocation t(5;14)(q35;q32) in three cases of childhood T‐cell acute lymphoblastic leukemia: a new recurring and cryptic abnormality. Leukemia 16: 7–12.

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Further Reading

Andreeff M and Pinkel D (1999) Introduction to Fluorescence in Situ Hybridization. Principles and Clinical Applications. New York, NY: Wiley‐Liss.

Rooney DE (2001) Constitutional analysis. In: Rooney DE and Czepulkowski B (eds.) Human Cytogenetics: A Practical Approach, 3rd edn. Oxford, UK: Oxford University Press.

Rooney DE (2001) Malignancy and acquired anomalies. In: Rooney DE and Czepulkowski B (eds.) Human Cytogenetics: A Practical Approach, 3rd edn. Oxford, UK: Oxford University Press.

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How to Cite close
Romana, Serge P, and Vekemans, Michel(Jan 2006) Clinical Molecular Cytogenetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005573]