Drosophila as a Model for Human Diseases


The fruit fly Drosophila melanogaster is a powerful genetic model organism that can be easily manipulated. Advanced tools have been constructed in Drosophila for disruption of genes (both somatic and germ line) as well as misexpression of endogenous and foreign transgenes. A high degree of similarity between these two proteomes suggests that as many as 74% of human diseaseā€causing genes could be studied in a Drosophila model.

Keywords: genetic model organism; drosophila melanogaster; disease; etiology; transgenics


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Web Links

Homophila. Human disease to Drosophila gene database http://homophila.sdsc.edu

Online Mendelian Inheritance in Man (OMIM) http://www.ncbi.nlm.nih.gov/omim/

Flybase. The FlyBase database of the Drosophila Genome Projects and community literature. The FlyBase Consortium http://flybase.bio.indiana.edu/

The Drosophila p‐screen database http://flypush.imgen.bcm.tmc.edu/pscreen/

The Homophila human disease gene to fly gene database http://homophila.sdsc.edu

Ubiquitin protein ligase E3A (human papilloma virus E6‐associated protein, Angelman syndrome) (UBE3A); Locus ID: 7337. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7337

Ubiquitin protein ligase E3A (human papilloma virus E6‐associated protein, Angelman syndrome) (UBE3A); MIM number: 601623. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?601623

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Reiter, Lawrence T(Jan 2006) Drosophila as a Model for Human Diseases. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005578]