Yeast as a Model for Human Diseases

Judith L Fridovich‐Keil, Emory University School of Medicine, Atlanta, Georgia, USA

Published online: January 2006

DOI: 10.1038/npg.els.0005581

Yeasts are single-celled eukaryotes that provide a genetically and biochemically amenable model system for biomedical research. Over the past decades, studies in yeast have established a foundation for much of our current knowledge on such fundamental processes as eukaryotic cell cycle control, genetic instability and colon cancer, metabolism and metabolic disease and even aging. Through basic science and pharmaceutical applications, studies in yeast hold promise for even greater contributions in the future.

Keywords: yeast; saccharomyces cerevisiae; human genetics; model systems; mutations

 References
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    book Adams A, Gottschling DE, Kaiser CA and Stearns T (1997) Methods in Yeast Genetics. Plainview, NY: Cold Spring Harbor Laboratory Press.
    book Broach JR, Pringle JR and Jones EW (1991) The Molecular and Cellular Biology of the Yeast Saccharomyces, vol. 1, Genome Dynamics, Protein Synthesis and Energetics Plainview, NY: Cold Spring Harbor Laboratory Press.
    book Jones EW, Pringle JR and Broach JR (1992) The Molecular and Cellular Biology of the Yeast Saccharomyces, vol. 2, Gene Expression Plainview, NY: Cold Spring Harbor Laboratory Press.
    book Pringle JR, Broach JR and Jones EW (1997) The Molecular and Cellular Biology of the Yeast Saccharomyces, vol. 3, Cell Cycle and Cell Biology Plainview, NY: Cold Spring Harbor Laboratory Press.
 Web Links
    ePath Saccharomyces Genome Database (SGD). This is a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae http://genome-www.stanford.edu/Saccharomyces/
    ePath The Wellcome Trust Sanger Institute: the S. pombe Genome Project. A useful resource for S. pombe genome project data as well as other tools and links http://www.sanger.ac.uk/Projects/S_pombe/
    ePath mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1). A resource for molecular biology and clinical information concerning MLH1; Locus ID: 4292. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4292
    ePath mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2). A resource for molecular biology and clinical information concerning MSH2; Locus ID: 4436. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4436
    ePath Werner syndrome (WRN); A resource for molecular biology and clinical information concerning WRN; Locus ID: 7486. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7486
    ePath mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1). Information on hereditary nonpolyposis colorectal cancer (HNPCC type 2); MIM number: 120436. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?120436
    ePath mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2). Information on hereditary nonpolyposis colorectal cancer (HNPCC type 1); MIM number: 120435. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?120435
    ePath Werner syndrome (WRN). Information on the WRN gene and encoded gene product; MIM number: 604611. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?604611

Related Sub-Topics:

Cell Cycle | Model Organisms and Human Disease | Techniques and Tools in Clinical Genetics | Genetic Models
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Article Title: Yeast as a Model for Human Diseases
 
How to Cite close
Fridovich‐Keil, Judith L(Jan 2006) Yeast as a Model for Human Diseases. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005581]