Dolly and Polly

Email a friend
Contact the editor about this article
How to cite

Dolly and Polly

Alan Petersen, University of Plymouth, Plymouth, UK

Published online: September 2006

DOI: 10.1002/9780470015902.a0005598

Full Article on Wiley Online Library

Abstract
References

Dolly, born in 1996, achieved notoriety by being the first mammal to be cloned from the nucleus of a fully differentiated cell, taken from the udder of an adult sheep. Polly, born a year after Dolly, was not only cloned but was also genetically transformed; that is, she carried an introduced gene that codes the protein factor IX, which is involved in blood clotting, which has huge therapeutic value.

Keywords: Dolly; Polly; cloning; pharming; nuclear transfer; reproductive cloning; therapeutic cloning

References
	Bloom FE (1997) Breakthroughs 1997. Science 278: 2029 (editorial).
	Butler D and Wadman M (1997) Calls for cloning ban sell science short. Nature 386(6620): 8–9.
	book Cooper DKC and Lanza RP (2000) Xeno: The Promise of Transplanting Animal Organs into Humans. Oxford, UK: Oxford University Press.
	book Kolata G (1997) Clone: The Road to Dolly and the Path Ahead. London, UK: The Penguin Press.
	McKinnell RG and Di Berardino MA (1999) The biology of cloning: history and rationale. Bioscience 49(11): 875–885.
	Meek J (2003) Dolly the sheep is put to sleep, aged only six. Guardian, 15 February: 8.
	Petersen A (2001) Biofantasies: genetics and medicine in the print news media. Social Science and Medicine 52: 1255–1268.
	book Petersen A and Bunton R (2002) The New Genetics and the Public's Health. London, UK: Routledge.
	book Rifkin J (1998) The Biotech Century: How Genetic Commerce Will Change the World. London, UK: Phoenix Press.
	Schnieke AE, Kind AJ, Ritchie WA, et al. (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278: 2130–2133.
	book Sexton S (2001) "If cloning is the answer, what was the question? Genetics and the politics of human health". In: Tokar B (ed.) Redesigning Life? The Worldwide Challenge to Genetic Engineering. London, UK: Zed Books.
	book Silver LM (1998) Remaking Eden: Cloning and Beyond in a Brave New World. London, UK: Weidenfeld and Nicolson.
	book Stock G and Campbell J (2000) Engineering the Human Germline: An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children. New York, NY: Oxford University Press.
	book Tagliaferro L and Bloom MV (1999) The Complete Idiot's Guide to Decoding Your Genes. New York, NY: Alpha Books.
	book Turney J (1998) Frankenstein's Footsteps: Science, Genetics and Popular Culture. New Haven, CT: Yale University Press.
	book Wilmut I, Campbell K and Tudge C (2000) The Second Creation: The Age of Biological Control by the Scientists Who Cloned Dolly. London, UK: Headline Book Publishing.
	Wilmut I, Schnieke AE, McWhir J, Kind AJ and Campbell KHS (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385(6619): 810–813.
Further Reading
	book House of Commons Science and Technology Committee (1997) The Cloning of Animals from Adult Cells, HC 373-1. London, UK: HMSO.
	Petersen A (2002) Replicating our bodies, losing our selves: news media portrayals of human cloning in the wake of Dolly. Body and Society 8(4): 71–90.
	book Ratala ML and Milgram AJ (1999) Cloning: For and Against. Chicago, IL: Open Court.
	book Wong DWS (1997) The ABCs of Gene Cloning New York, NY: Chapman & Hall.
Web Links
	ePath The Human Genetics Commission (HGC). Cloning Issues in Reproduction, Science and Medicine (issued January 1998) http://www.hgc.gov.uk/business_publications.htm#reports
	ePath PPL Therapeutics http://www.ppl-therapeutics.com

Article Title:	Dolly and Polly
* Name:
* E-mail:
* Note:

Dolly and Polly

Related Sub-Topics: