Medical Genetics in Britain: Laying the Foundation (1940s–1960s)

Abstract

Medical genetics refers to the use of genetic information in the healthcare setting. This includes research efforts to understand the genetic basis of human illness. It also includes clinical services that use genetic knowledge to provide an assessment of risk for the occurrence of gene‐based disorders, determine an individual's actual genetic status, select treatments and develop programmes of disease prevention. In Britain, medical genetics as an area of specialty arose out of the activities begun in three separate settings during the period from mid‐1940s through the 1960s: the Clinical Genetics Research Unit at the Institute of Child Health in London, the Paediatric Research Unit at Guy's Hospital in London and the Nuffield Unit of Medical Genetics at the University of Liverpool Medical School. The research and clinical commitments of these separate units and the strong links connecting them provided the foundation on which present‐day medical genetics is built.

Key concepts:

  • Medical genetics, as an area of speciality, emerged late in the twentieth century in Britain largely through the efforts of physicians who, for the most part, had no formal training in genetics but who recognized its importance.

  • Activities undertaken at three separate medical units, each emphasizing different aspects of genetics (pedigree analysis, cytogenetics and genetic variation associated with common disorders), formed the foundation on which medical genetics, as an entity, developed.

  • Medical genetics was able to grow and establish itself more widely because of the many different types of close interactions among the members of the three founding groups and the support received from existing medical institutions.

Keywords: blood group research; genetic counselling; cytogenetics; Rh disease; medical genetics

References

Aird I, Bentall HH and Roberts JAF (1953) A relationship between cancer of stomach and the ABO blood groups. British Medical Journal 1: 799–801.

Bodmer WF (1992) Early British discoveries in human genetics: contributions of RA Fisher and JBS Haldane to the development of blood groups. American Journal of Human Genetics 50: 671–676.

Clark R (1972) A Biography of the Nuffield Foundation. London, UK: Longman.

Dodsworth H (1993) Dame Janet Vaughan (1899–1993). In: Bindman L, Brading A and Tansey T(eds) Women Physiologists, pp. 31–36. London, UK: Portland Press.

Ford EB (1964) Ecological Genetics. London, UK: Methuen.

Kevles DL (1985) In the Name of Eugenics: Genetics and the Uses of Human Heredity. New York: Alfred A Knopf.

Paul D (1995) Controlling Human Heredity: 1865 to the Present. Atlantic Highlands, NJ: Humanities Press.

Pembrey M (1984) In Memoriam: Professor C. O. Carter. American Journal of Medical Genetics 19: 1–3.

Polani PE (1992) John Alexander Fraser Roberts. Biographical Memoirs of Fellows of the Royal Society 38: 307–322.

Polani PE, Alberman E, Alexander BJ et al. (1979) Sixteen years' experience of counseling, diagnosis, and prenatal detection in one genetic centre: progress, results, and problems. Journal of Medical Genetics 16: 166–175.

Tjio JH and Levan A (1956) The chromosome number of man. Hereditas 42: 1–6.

Zallen D (1999) From butterflies to blood: human genetics in the United Kingdom. In: Fortun M and Mendelsohn E (eds) The Practices of Human Genetics, pp. 197–216. Oxford, UK: Kluwer Academic Publishers.

Further Reading

Clarke CA and Finn R (1977) Prevention of Rh hemolytic disease: background of the Liverpool work. American Journal of Obstetrics and Gynecology 127: 538–539.

Ford CE and Hamerton JL (1956) The chromosomes of man. Nature 178: 1020–1023.

Harper PA, Reynolds LA and Tansey EM (eds) (2009) Clinical genetics in Britain: Origins and development. Wellcome Witnesses to Twentieth Century Medicine, vol. 39 Freely available online at www.ucl.ac.uk/histmed/publications/wellcome‐witnesses/index.html or following the links to Publications/Wellcome Witnesses from www.ucl.ac.uk/histmed. London: The Wellcome Trust Centre for the History of Medicine at UCL.

Harper PW (2008) A Short History of Medical Genetics (Oxford Monographs on Medical Genetics). Oxford, UK: Oxford University Press.

Mollison PL (1994) The genetic basis of the Rh blood group system. Transfusion 34: 539–541.

Polani PE (1990) The Impact of Genetics on Medicine. Harveian Oration of 1988 (October 18, 1988). London, UK: Royal College of Physicians.

Weatherall D (1994) The Nuffield Department of Clinical Medicine. In: Minns FJ (ed.) Wealth Well‐given: The Enterprise and Benevolence of Lord Nuffield, pp. 152–166. Strail, UK: Alan Sutton Publishing.

Zallen DT, Christie DA and Tansey EM (eds) (2004) The Rhesus Factor and Disease Prevention. Wellcome Witnesses to Twentieth Century Medicine, vol. 22 Freely available online at www.ucl.ac.uk/histmed/publications/wellcome‐witnesses/index.html or following the links to Publications/Wellcome Witnesses from www.ucl.ac.uk/histmed. London: Wellcome Trust Centre for the History of Medicine at UCL.

Zimmerman D (1973) Rh: The Intimate History of a Disease and its Conquest. New York: Macmillan.

Web Links

RHD (Rhesus blood group, D antigen); LocusID: 6007. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6007

RHD (Rhesus blood group, D antigen); MIM number: 111680. OMIM: http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?111680

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How to Cite close
Zallen, Doris T(Dec 2009) Medical Genetics in Britain: Laying the Foundation (1940s–1960s). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005603.pub2]