RF Mueller, University of Leeds, Leeds, UK
Published online: September 2006
DOI: 10.1002/9780470015902.a0005628
Consanguineous marriages are uncommon in Western Europe and North America, whereas in many other parts of the world consanguineous marriage predominates. While consanguinity is routinely enquired after when obtaining a family history during genetic counseling, careful consideration should be given to the possible meaning attributed to that enquiry.
Keywords: close relative; genetic disorder; cousin; inheritance; autosomal recessive; genetic counseling; consanguinity; risks; ethnicity
| References | |
| Bittles AH, Mason WM, Greene J and Rao NA (1991) Reproductive behavior and health in consanguineous marriages. Science 252: 789–794. | |
| Bittles AH and Neel JV (1994) The costs of human inbreeding and their implications for variations at the DNA level. Nature Genetics 8: 117–121. | |
| Bundey S and Alam H (1993) A five-year prospective study of the health of children in different ethnic groups, with particular reference to inbreeding. European Journal of Human Genetics 1: 206–219. | |
| Fraser FC and Biddle CJ (1976) Estimating the risks for offspring of first cousin matings. American Journal of Human Genetics 28: 522–526. | |
| Garrod AE (1908) Inborn errors of metabolism. Lancet ii: 1–7, 73–79, 142–148, 214–220. | |
| Mueller RF and Bishop DT (1993) Complex consanguinity and homozygosity mapping. Journal of Medical Genetics 30: 798–799. | |
| Slatis HM, Reis RH and Hoene RE (1958) Consanguineous marriages in the Chicago region. American Journal of Human Genetics 10: 446–464. | |
| Stoltenberg C, Magnus P, Skrondul A and Lie RT (1999) Consanguinity and recurrence risk of birth defects: a population-based study. American Journal of Medical Genetics 82: 423–428. | |
| other WHO (1985) Report of a WHO Advisory Group on Hereditary Diseases. Document HMG/WG/85.8a. | |
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