Human Genome Project as a Social Enterprise

Abstract

As a social enterprise, the Human Genome Project (HGP) can be understood in a number of different ways, including the social organisation of science, the influence of society and culture on scientific work and the influence of scientific findings and endeavours on society. The HGP introduced new forms of organisation to the biological and biomedical sciences; these include the entrance of ‘Big Science’ modes of organisation, automation and routinisation. Disagreements between the public HGP and private projects were based on different aims, organisation and guiding norms. In particular, there is a tension between the norm of collaboration in science and the role of competition. Despite concerns that the HGP would promote genetic determinism and even eugenics, these fears have not been realised.

Key Concepts

  • The founding and funding of the Human Genome Project required advocacy from government departments and agencies, prominent scientists and support in the US Congress; there was opposition within and without the scientific community.
  • The Human Genome Project was an international collaboration that required models of organisation appropriate to ensure coordination between the centres that conducted the sequencing.
  • The project has been conceived as an example of ‘Big Science’ and also ‘Fast Science’; it brought new ways of organising research into the biological sciences.
  • The opposition of the public Human Genome Project and private sector initiative centred on organisation, the values of collaboration and/or competition and the dissemination and prospective use of the data generated by sequencing.
  • Fears that the Human Genome Project would provide support for eugenics and genetic determinism have not been realised.

Keywords: human genome project; big science; collaboration; competition; genomics; sequencing

References

Barnes B and Dupré J (2008) Genomes and What to Make of Them. Chicago, IL: The University of Chicago Press.

Bostanci A (2004) Sequencing human genomes. In: Gaudillière JP and Rheinberger HJ (eds) From Molecular Genetics to Genomics: The Mapping Cultures of Twentieth‐Century Genetics, pp. 158–179. Abingdon: Routledge.

Bubela TM and Caulfield TA (2004) Do the print media “hype” genetic research? A comparison of newspaper stories and peer‐reviewed research papers. CMAJ 170 (9): 1399–1407.

Carver R, Waldahl R and Breivik J (2008) Frame that gene: a tool for analysing and classifying the communication of genetics to the public. EMBO Reports 9 (10): 943–947.

Condit CM (2007) Science and society: how geneticists can help reporters to get their story right. Nature Reviews Genetics 8: 815–820.

Davis BD, Amos H, Beckwith JR, et al. (1990) The human genome and other initiatives. Science 249 (4967): 342–343.

Fortun M (1997) Projecting speed genomics. In: Fortun M and Mendelsohn E (eds) The Practices of Human Genetics, pp. 25–48. Dordrecht: Springer.

Hilgartner S (2004) Making maps and making social order: Governing American genome centers, 1988–1993. In: Gaudillière JP and Rheinberger HJ (eds) From Molecular Genetics to Genomics: The Mapping Cultures of Twentieth‐Century Genetics, pp. 202–218. Abingdon: Routledge.

Hilgartner S (2013) Constituting large‐scale biology: building a regime of governance in the early years of the Human Genome Project. BioSocieties 8: 397–416.

International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431: 931–945.

Keller EF (2000) The Century of the Gene. Cambridge, MA: Harvard University Press.

Latour B (1987) Science in Action: How to Follow Scientists and Engineers through Society. Cambridge, MA: Harvard University Press.

Lewontin RC, Rose S and Kamin L (1984) Not in Our Genes: Biology, Ideology, and Human Nature. London: Penguin Books.

Lewontin RC (2000) It Ain't Necessarily So: The Dream of the Human Genome and Other Illusions. London: Granta Books.

Markel H (2013) Patents, profits, and the American people – The Bayh–Dole Act of 1980. The New England Journal of Medicine 369: 794–796.

Merton RK [1942] (1973) The normative structure of science. In: Merton RK (ed.) The Sociology of Science: Theoretical and Empirical Investigations, pp. 267–280. Chicago, IL: The University of Chicago Press.

Parkinson J and Blaxter M (2009) Expressed sequence tags: an overview. Methods in Molecular Biology 533: 1–12.

Powell WW and Snellman K (2004) The knowledge economy. Annual Review of Sociology 30 (1): 199–220.

Schacht WH (2012) The Bayh‐Dole Act: Selected Issues in Patent Policy and the Commercialization of Technology. Congressional Research Service Report for Congress.

Sunder Rajan K (2006) Biocapital: The Constitution of Postgenomic Life. Durham, NC: Duke University Press.

Further Reading

Balmer B (1996) Managing mapping in the Human Genome Project. Social Studies of Science 26: 531–573.

Balmer B (1996) The political cartography of the Human Genome Project. Perspectives on Science 4 (3): 249–282.

Dupré J (2004) Understanding contemporary genomics. Perspectives on Science 12: 320–338.

Fujimura JH (1999) The practices and politics of producing meaning in the Human Genome Project. Sociology of the Sciences Yearbook 21 (1): 49–87.

Gannett L (2014) The Human Genome Project. In: Zalta EN (ed.) The Stanford Encyclopedia of Philosophy. Available online at: http://plato.stanford.edu/archives/win2014/entries/human‐genome/.

Moore AD (2000) Owning genetic information and gene enhancement techniques: why privacy and property rights may undermine social control of the human genome. Bioethics 14: 97–119.

National Human Genome Research Institute (2016) Genome.gov

Tempini N and Leonelli S (2015) Human Genome Project, Personalised Medicine and Future Health Care. eLS Encyclopedia of the Life Sciences. London: Wiley‐Blackwell.

Watson JD (1990) The Human Genome Project: past, present, and future. Science 248: 44–49.

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Lowe, James WE(Nov 2016) Human Genome Project as a Social Enterprise. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005650.pub2]