Gene Therapy: Expectations and Results


Industry has invested heavily in gene therapy since the first clinical trial in 1989. Ethical debates, regulations and public expectations have had a major impact on its commercial development.

Keywords: gene therapy; biotechnology industry; public perception; clinical development; ethics


Cavazzana‐Calvo M, Hacein‐Bey S, de Saint Basile G, et al. (2000) Gene therapy of human severe combined immunodeficiency (SCID)‐X1 disease. Science 288 (April 28): 669–672.

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Further Reading

Lyon J and Gorner P (1996) Altered Fates: Gene Therapy and the Retooling of Human Life. New York, NY: WW Norton.

McCormick F (2001) Cancer gene therapy: fringe or cutting edge? Nature Reviews Cancer 1(2): 130–141.

Scollay R (2001) Gene therapy: a brief overview of the past, present, and future. Annals of the New York Academy of Sciences 953: 26–30. [Also see series of other articles in the same volume.]

Web Links

Journal of Gene Medicine. Provides profiles of leading gene therapy firms.

Human Genome Project Information. Introduction to Gene Therapy

National Reference Center for Bioethics Literature Scope Note 24: Outline of the history of the main ethical debates.

Office of Biotechnology Activities. Recombinant DNA and Gene Transfer. Information on regulations and current developments.

National Heart, Lung and Blood Institute. Programs of Excellence in Gene Therapy. Links to leading research centres.

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How to Cite close
Martin, Paul A(Sep 2006) Gene Therapy: Expectations and Results. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0005653]