Hanno Steen, Harvard Medical School, Boston, Massachusetts, USA
Akhilesh Pandey, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005713
Proteomics is the large-scale identification and characterization of proteins and posttranslational modifications. Several proteomic methodologies, especially microarrays and mass spectrometry, offer the promise of use in a variety of clinical settings.
Keywords: mass spectrometry; genomics; posttranslational modifications; diagnostic markers; chips
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| Further Reading | |
| Aebersold R and Goodlett DR (2001) Mass spectrometry in proteomics. Chemical Reviews 101: 269–296. | |
| Alaiya AA, Franzen B, Auer G and Linder S (2000) Cancer proteomics: from identification of novel markers to creation of artificial learning models for tumor classification. Electrophoresis 21: 1210–1217. | |
| Banks RE, Dunn MJ, Hochstrasser DF, et al. (2000) Proteomics: new perspectives, new biomedical opportunities. Lancet 356: 1749–1756. | |
| book Links AJ (ed.) (1999) 2-D Proteome Analysis Protocols. Totowa, NJ: Humana Press Inc | |
| Parekh RB and Rohlff C (1997) Post-translational modification of proteins and the discovery of new medicine. Current Opinion in Biotechnology 8: 718–723. | |
| book Wilkins MR, Williams KL, Appel RD and Hochstrasser DF (eds.) (1997) Proteome Research: New Frontiers in Functional Genomics. (Principles and Practice). New York, NY: Springer-Verlag. | |
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