DNA Viral Vectors in Gene Therapy


DNA viral vectors are gene‐delivery vehicles based on viral sequences.

Keywords: simian virus 40; baculovirus; vaccinia virus; Epstein–Barr virus; gene transfer


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Further Reading

Boyce FM and Bucher NL (1996) Baculovirus‐mediated gene transfer into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 93: 2348–2352.

Carrol MW and Moss B (1997) Poxviruses as expression vectors. Current Opinion in Biotechnology 8: 573–577.

Dwarakanath RS, Clark CL, McElroy AK and Spector DH (2001) The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts. Virology 284: 297–307.

Goebel SJ, Johnson GP, Perkus ME, et al. (1990) The complete DNA sequence of vaccinia virus. Virology 179: 247–266, 517–563.

Mackett M (1995) Construction and characterization of vaccinia virus recombinants. In: Glover D (ed.) DNA Cloning. 4. Mammalian Systems: A Practical Approach, pp. 43–83. New York, NY: Oxford University Press.

Moss B (1996) Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. Proceedings of the National Academy of Sciences of the United States of America 93: 11341–11348.

Shoji I, Aizaki H, Tani H, et al. (1997) Efficient gene transfer into various mammalian cells, including non‐hepatic cells, by baculovirus vectors. Journal of General Virology 78: 2657–2664.

Strayer DS (2000) SV40‐based gene therapy vectors: turning an adversary into a friend. Current Opinion in Molecular Therapy 2: 570–578.

Van Craenenbroeck K, Vanhoenacker P and Haegeman G (2000) Episomal vectors for gene expression in mammalian cells. European Journal of Biochemistry 267: 5665–5678.

Verma IM and Somia N (1997) Gene therapy – promises, problems and prospects. Nature 389: 239–242.

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Van Craenenbroeck, Kathleen, Vanhoenacker, Peter, and Haegeman, Guy(Jan 2006) DNA Viral Vectors in Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005740]