DNA viral vectors are gene-delivery vehicles based on viral sequences.
Keywords: simian virus 40; baculovirus; vaccinia virus; Epstein–Barr virus; gene transfer
DNA Viral Vectors in Gene Therapy
Kathleen Van Craenenbroeck, University of Gent, Gent, Belgium
Peter Vanhoenacker, University of Gent, Gent, Belgium
Guy Haegeman, University of Gent, Gent, Belgium
Published online: January 2006
DOI: 10.1038/npg.els.0005740
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| Further Reading | |
| Boyce FM and Bucher NL (1996) Baculovirus-mediated gene transfer into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 93: 2348–2352. | |
| Carrol MW and Moss B (1997) Poxviruses as expression vectors. Current Opinion in Biotechnology 8: 573–577. | |
| Dwarakanath RS, Clark CL, McElroy AK and Spector DH (2001) The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts. Virology 284: 297–307. | |
| Goebel SJ, Johnson GP, Perkus ME, et al. (1990) The complete DNA sequence of vaccinia virus. Virology 179: 247–266, 517–563. | |
| book Mackett M (1995) "Construction and characterization of vaccinia virus recombinants". In: Glover D (ed.) DNA Cloning. 4. Mammalian Systems: A Practical Approach, pp. 43–83. New York, NY: Oxford University Press. | |
| Moss B (1996) Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. Proceedings of the National Academy of Sciences of the United States of America 93: 11341–11348. | |
| Shoji I, Aizaki H, Tani H, et al. (1997) Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. Journal of General Virology 78: 2657–2664. | |
| Strayer DS (2000) SV40-based gene therapy vectors: turning an adversary into a friend. Current Opinion in Molecular Therapy 2: 570–578. | |
| Van Craenenbroeck K, Vanhoenacker P and Haegeman G (2000) Episomal vectors for gene expression in mammalian cells. European Journal of Biochemistry 267: 5665–5678. | |
| Verma IM and Somia N (1997) Gene therapy – promises, problems and prospects. Nature 389: 239–242. | |
