RNA Viral Vectors in Gene Therapy

Stephen J Russell, Mayo Clinic, Rochester, Minnesota, USA

Published online: January 2006

DOI: 10.1038/npg.els.0005743

Genes can be delivered into mammalian cells using synthetic nonviral vectors or recombinant viral vectors derived from DNA virsuses, retroviruses and, more recently, RNA viruses.

Keywords: RNA viruses; gene transfer; poliovirus; measles virus; vesicular stomatitis virus; influenza virus; Sindbis virus

 Further Reading
    Evans DJ (1999) Reverse genetics of picornaviruses. Advances in Virus Research 53: 209–228.
    book Griffin D (2001) "Alphaviruses". In: Knipe D and Howley P (eds.) Field's Virology, pp. 917–962. Philadelphia, PA: Lippincott, Williams & Wilkins.
    book Lamb R and Kolakofsky D (2001) "Paramyxoviridae: the viruses and their replication". In: Knipe D and Howley P (eds.) Field's Virology, pp. 1305–1340. Philadelphia, PA: Lippincott, Williams & Wilkins.
    book Lamb R and Krug R (2001) "Orthomyxoviridae: the viruses and their replication". In: Knipe D and Howley P (eds.) Field's Virology, pp. 1487–1531. Philadelphia, PA: Lippincott, Williams & Wilkins.
    Nagai Y (1999) Paramyxovirus replication and pathogenesis. Reverse genetics transforms understanding. Reviews in Medical Virology 9: 83–99.
    Neumann G and Kawaoka Y (2001) Reverse genetics of influenza virus. Virology 287: 243–250.
    book Racaniello V (2001) "Picornaviridae: the viruses and their replication". In: Knipe D and Howley P (eds.) Field's Virology, pp. 685–722. Philadelphia, PA: Lippincott, Williams & Wilkins.
    Roberts A, Buonocore L, Price R, Forman J and Rose JK (1999) Attenuated vesicular stomatitis viruses as vaccine vectors. Journal of Virology 73: 3723–3732.
    book Rose J and Whitt M (2001) "Rhabdoviridae: the viruses and their replication". In: Knipe D and Howley P (eds.) Field's Virology, pp. 1221–1244. Philadelphia, PA: Lippincott, Williams & Wilkins.
    Schlesinger S (2000) Alphavirus expression vectors. Advances in Virus Research 55: 565–577.

Related Sub-Topics:

Viruses in Gene Therapy | RNA Viruses | Virus Replication | Techniques and Tools in Clinical Genetics | Gene Therapy
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Article Title: RNA Viral Vectors in Gene Therapy
 
How to Cite close
Russell, Stephen J(Jan 2006) RNA Viral Vectors in Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005743]