Naked DNA in Gene Therapy

Dexi Liu, University of Pittsburgh School of Pharmacy, Pennsylvania, USA
Etsuko Satoh, University of Pittsburgh School of Pharmacy, Pennsylvania, USA
Joseph E Knapp, University of Pittsburgh School of Pharmacy, Pennsylvania, USA

Published online: January 2006

DOI: 10.1038/npg.els.0005744

‘Naked DNA’ is DNA without an association with any synthetic or naturally occurring compounds. Significant progress has been made in the use of naked DNA for gene delivery.

Keywords: electroporation; gene therapy; hydrodynamic DNA delivery; naked DNA; nonviral vector

 References
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 Further Reading
    book Huang L, Wagner E and Hung MC (1999) Nonviral Vectors for Gene Therapy. San Diego, CA: Academic Press.
    Jaroszeski MJ and Malone RW (2000) Theory and in vivo application of electroporative gene delivery. Molecular Therapy 2: 178–187.
    Liu D and Knapp JE (2001) Hydrodynamics-based gene delivery. Current Opinion in Molecular Therapeutics 3: 192–197.
    Liu MA and Ulmer JB (2000) Gene-based vaccines. Molecular Therapy 6: 497–500.
    book Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.

Related Sub-Topics:

Techniques and Tools in Clinical Genetics | Gene Therapy | Nonchromosomal DNA
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Article Title: Naked DNA in Gene Therapy
 
How to Cite close
Liu, Dexi, Satoh, Etsuko, and Knapp, Joseph E(Jan 2006) Naked DNA in Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005744]