Regulatable Gene Expression in Gene Therapy


The regulation of exogenous gene expression may soon be a requirement for gene therapy approaches. Several systems promise to fulfill requirements for clinical applications.

Keywords: inducible gene expression; tetracycline; ecdyson; rapamycin/rapalogs; RU486; gene therapy; iathrogenic effects


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Further Reading

Corbel SY and Rossi FM (2002) Latest developments and in vivo use of the Tet system: ex vivo and in vivo delivery of tetracycline‐regulated genes. Current Opinion in Biotechnology 13(5): 448–452.

Weber W, Fux C, Daoud‐el Baba M, et al. (2002) Macrolide‐based transgene control in mammalian cells and mice. Nature Biotechnology 20(9): 901–907.

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Rossi, Fabio(Jan 2006) Regulatable Gene Expression in Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005748]