Gene Transfer in Transplantation


The introduction of genetic information into tissues or organs to be transplanted aims to confer new biological properties on the grafts. Gene transfer has already shed light on the basic mechanisms of graft rejection and tolerance, and has the potential to be applied in the clinic.

Keywords: transplantation; gene therapy; transgenesis; inflammation; cytokines; costimulation

Figure 1.

Gene transfer strategies in transplantation.



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Further Reading

Asahara T, Kalka C and Isner JM (2000) Stem cell therapy and gene transfer for regeneration. Gene Therapy 7: 451–457.

Bach F, Hancock W and Ferran C (1997) Protective genes expressed in endothelial cells: a regulatory response to injury. Immunology Today 18: 483–486.

Bluestone JA (1996) Costimulation and its role in organ transplantation. Clinical Transplantation 10: 104–109.

Cohen JL, Boyer O and Klatzmann D (1999) Would suicide gene therapy solve the T‐cell dilemma of allogeneic bone marrow transplantation? Immunology Today 20: 172–176.

Cuturi MC, Blancho G, Josien R and Soulillou JP (1994) The biology of allograft rejection. Current Opinion in Nephrology and Hypertension 3: 578–584.

Nickerson P, Steiger J, Xiao Zheng X, et al. (1997) Manipulation of cytokine networks in transplantation. False hope or realistic opportunity for tolerance. Transplantation 63: 489–494.

Waldmann H (1999) Transplantation tolerance – where do we stand? Nature Medicine 5: 1245–1248.

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How to Cite close
Anegon, Ignacio(Jan 2006) Gene Transfer in Transplantation. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005760]