Infectious Diseases: Gene Therapy


Human gene therapy is defined as the introduction of new genetic material into the cells of an individual with the intention of producing a therapeutic benefit for that individual. Gene therapy may be applied to any infectious disease whereby the infecting organism inserts its own genetic material into the genome of the host cell genome.

Keywords: infectious diseases; human immunodeficiency virus; gene therapy

Figure 1.

HIV life cycle. See main text for further details.

Figure 2.

Antiviral constructs for HIV gene therapy. See main text for further details.

Figure 3.

Antiviral constructs: ribozymes and antisense RNA. See main text for further details.

Figure 4.

Antiviral constructs: decoy RNA. See main text for further details.

Figure 5.

Intracellular antibodies. See main text for further details. ER: endoplasmic reticulum.

Figure 6.

Antiviral constructs: dominant negative mutants. See main text for further details.



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Further Reading

Anderson WF (1992) Human gene therapy. Science 256: 808–813.

Bunnell BA and Morgan RA (1998) Gene therapy for infectious diseases. Clinical Microbiology Reviews 11: 42–56.

Yu M, Poeschla E and Wong‐Staal F (1994) Progress towards gene therapy for HIV infection. Gene Therapy Review 1: 13–26.

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How to Cite close
Fidler, S, and Weber, J(Jan 2006) Infectious Diseases: Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005761]