Hematopoietic Stem Cells

Abstract

Hematopoietic stem cells are the common ancestor to every type of blood cell. They undergo massive proliferation and differentiation to produce billions of red blood cells, white blood cells and platelets.

Keywords: blood; hematopoietic stem cell; transplantation

Figure 1.

Hematopoiesis and gene transduction. Pluripotent hematopoietic stem cells undergo self‐renewal or commitment to differentiation under the influence of hematopoietic growth factors produced from the bone marrow stromal cells (e.g. interleukin‐6 (IL‐6), stem cell factor (SCF), granulocyte–monocyte colony stimulating factor (GM‐CSF), flt‐3 ligand (FL) and thrombopoietin (TPO)). Progenitor cells proliferate and differentiate along pathways of increasingly restricted developmental potential to produce mature blood cells. CFU‐GM: granulocyte–monocyte colony‐forming unit; CFU‐GEMM: granulocyte–erythrocyte–monocyte–megakaryocyte colony‐forming unit; BFU‐E: burst‐forming unit‐erythroid.

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References

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Further Reading

Civil CI (1990) Mini‐review: human monomyeloid cell membrane antigens. Experimental Hematology 18: 461–467.

Goldman J (1998) Hematopoietic stem cell transplantation. Current Opinion in Hematology 5: 417–418.

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Weissman IL (2000) Stem cells: units of development, units of regeneration, and units in evolution. Cell 100: 157–168.

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Kohn, Donald B, Nolta, Jan A, and Crooks, Gay M(Jan 2006) Hematopoietic Stem Cells. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005764]