Mitosis: Chromosomal Rearrangements

Abstract

Chromosomal rearrangements occur during mitosis as a result of chromosomal breakage and rejoining. Such chromosomal rearrangement occurs more frequently in cancer cells than during embryogenesis or postnatally, usually as a result of environmental exposures and/or mutations resulting in DNA repair defects.

Keywords: chromosomal instability; breakage–fusion–bridge cycle; gene amplification; chromosomal rearrangement; cancer

References

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Web Links

APC (adenomatosis polyposis coli); LocusID: 324. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=324

APC (adenomatosis polyposis coli); MIM number: 175100. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?175100

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How to Cite close
Gollin, Susanne M, and Skarja, Shalini Reshmi(Jan 2006) Mitosis: Chromosomal Rearrangements. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005773]