Susanne M Gollin, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Shalini Reshmi Skarja, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005773
Chromosomal rearrangements occur during mitosis as a result of chromosomal breakage and rejoining. Such chromosomal rearrangement occurs more frequently in cancer cells than during embryogenesis or postnatally, usually as a result of environmental exposures and/or mutations resulting in DNA repair defects.
Keywords: chromosomal instability; breakage–fusion–bridge cycle; gene amplification; chromosomal rearrangement; cancer
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| Further Reading | |
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| Web Links | |
| ePath APC (adenomatosis polyposis coli); LocusID: 324. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=324 | |
| ePath APC (adenomatosis polyposis coli); MIM number: 175100. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?175100 | |
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