Peter S White, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Published online: September 2007
DOI: 10.1002/9780470015902.a0005810.pub2
Human chromosome 1 is the largest human chromosome. This metacentric chromosome, which contains 8% of the genetic material in the genome, is characterized by several gene clusters, including the epidermal differentiation complex, and genes predisposing to a large number of human diseases.
Keywords: chromosome 1; sequencing; gene cluster; disease; maps
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| Further Reading | |
| Gregory SG, Barlow KF, McLay KE et al. (2006) The DNA sequence and biological annotation of human chromosome 1. Nature 441: 315–321. | |
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| Schutte BC, Carpten JD, Forus A et al. (2001) Report of the sixth international workshop on human chromosome 1 mapping 2000. Cytogenetics and Cell Genetics 92: 23–41. | |
| South AP, Cabral A, Ives JH et al. (1999) Human epidermal differentiation complex in a single 2.5 Mbp long continuum of overlapping DNA cloned in bacteria integrating physical and transcript maps. Journal of Investigative Dermatology 112: 910–918. | |
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