Susan L Naylor, University of Texas Health Science Center, San Antonio, Texas, USA
Dawn K Garcia, University of Texas Health Science Center, San Antonio, Texas, USA
Published online: January 2006
DOI: 10.1038/npg.els.0005812
Human chromosome 3 is the third largest chromosome, containing ~7% of the genetic material in the genome. This metacentric chromosome contains the most common fragile site as well as clusters of olfactory receptor and chemokine receptor genes.
Keywords: chromosome 3, gene mapping; comparative mapping; fragile site; genetic disease
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| Further Reading | |
| book Brown TA (1999) Genomes. New York, NY: John Wiley. | |
| book Gibson G and Muse SV (2001) A Primer of Genome Science Sunderland, MA: Sinauer Associates. | |
| Higgins JJ, Rosen DR, Loveless JM, et al. (2000) A gene for nonsyndromic mental retardation maps to chromosome 3p25-pter. Neurology 8: 328–330. | |
| Pras E, Pras E, Bakhan T, et al. (2001) A gene causing autosomal recessive cataract maps to the short arm of chromosome 3. Israeli Medical Association Journal 3: 559–562. | |
| book Witherly JL (2001) An A to Z of DNA Science: What Scientists Mean When They Talk About Genes and Genomes. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. | |
| Web Links | |
| ePath Baylor HGSC. Sequencing of chromosome 3 http://www.hgsc.bcm.tmc.edu | |
| ePath Center for Medical Genetics. Marshfield map http://research.marshfieldclinic.org/genetics | |
| ePath CGAP (Cancer Genome Anatomy Project). The National Cancer Institute has undertaken a Cancer Genome Anatomy Project. It is a repository molecular data for genes, chromosomes, and tissues in human and mouse http://cgap.nci.nih.gov | |
| ePath eGenome. eGenome is another representation of data for the human genome. The site emphasizes a map view of polymorphisms and transcribed sequences. http://egenome.chop.edu | |
| ePath Ensembl Genome Browser. This a highly detailed site created by the European Bioinformatics Group. Information from gene loci to SNPs to ESTs is represented in an interactive manner from the whole entity to the single nucleotide http://www.ensembl.org | |
| ePath European Bioinformatics Institute. radiation hybrid map http://www.ebi.ac.uk | |
| ePath Fondation Jean Dausset – CEPH. CEPH–Genethon map http://www.cephb.fr | |
| ePath Genome Channel http://compbio.ornl.gov/channel/index.html | |
| ePath Genome Database http://www.gdb.org | |
| ePath Genome Sequencing Center. Fingerprint contig generated by Washington University http://genome.wustl.edu | |
| ePath Human Telomere Mapping and Sequencing Project. This site indicates the information available for human telomeres – clones that have been isolated and sequence that is available http://www.wistar.upenn.edu/Riethman | |
| ePath Max Planck Institute for Molecular Genetics. Sequencing projects http://seq.mpimg-berlin-dahlem.mpg.de/ | |
| ePath Mouse Genome Informatics (MGI 2.8) http://www.informatics.jax.org | |
| ePath NCBI (National Center for Biotechnology Information) SNP; BACs that have been FISH-mapped to chromosome 3; radiation hybrid map http://www.ncbi.nlm.nih.gov | |
| ePath Online Mendelian Inheritance in Man (OMIM) OMIM is a catalog of human genes and genetic disorders http://www3.ncbi.nlm.nih.gov/Omim/ | |
| ePath San Antonio Genome Center. Tiling path for chromosome 3 http://apollo.uthscsa.edu | |
| ePath Stanford Human Genome Center. radiation hybrid map http://shgc-www.stanford.edu | |
| ePath UCSC Genome Bioinformatics. BAC maps http://genome.ucsc.edu | |
| ePath University of Washington Genome Center. This database has been key in constructing human BAC contigs. In addition the site provides information on regions it has sequenced as well as SNP and EST data http://www.genome.washington.edu | |
| ePath TCTA(T-cell leukemia translocation altered gene); Locus ID: 6988. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6988 | |
| ePath TP63(tumor protein p63); Locus ID: 8626. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=8626 | |
| ePath TCTA(T-cell leukemia translocation altered gene); MIM number: 600690. OMIM: http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?600690 | |
| ePath TP63(tumor protein p63); MIM number: 603273. OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?cmd=entry&id=603273 | |
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