Chromosome 5

Abstract

Human chromosome 5 is a submetacentric chromosome containing some 6% of the genetic material in the genome. It is characterized by many gene clusters including those encoding interleukins, protocadherins and complement proteins.

Keywords: chromosome 5; complex genetic diseases; spinal muscular atrophy; asthma; interleukin gene cluster; Cri du chat; acute myelogenous leukemia; protocadherin

References

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Further Reading

Fairman J, Chumakov I, Chinault AC, Nowell PC and Nagarajan L (1995) Physical mapping of the minimal region of loss in 5q‐ chromosome. Proceedings of the National Academy of Sciences of the United States of America 92: 7406–7410.

Fischer U, Liu Q and Dreyfuss G (1997) The SMN–SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell 90: 1023–1029.

Gu Z, Wang H, Nekrutenko A and Li WH (2000) Densities, length proportions, and other distributional features of repetitive sequences in the human genome estimated from 430 megabases of genomic sequence. Gene 259: 81–88.

Horrigan SK, Arbieva ZH, Xie HY, et al. (2000) Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31. Blood 95: 2372–2377.

Liu Q, Fischer U, Wang F and Dreyfuss G (1997) The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90: 1013–1021.

Niebuhr E (1978) The cri du chat syndrome: epidemiology, cytogenetics, and clinical features. Human Genetics 44: 227–275.

Pellizzoni L, Charroux B, Rappsilber J, Mann M and Dreyfuss G (2001) A functional interaction between the survival motor neuron complex and RNA polymerase II. Journal of Cell Biology 152: 75–85.

Web Links

CGAP–Mitelman Database http://cgap.nci.nih.gov/Chromosomes/Mitelman

DOE Joint Genome Institute. Tiling map of chromosome 5 http://www.jgi.doe.gov/programs/hgp.html

EMBL‐EBI Ensembl Human Genome Browser http://www.ensembl.org/Homo_sapiens

Ensembl DiseaseView http://www.ensembl.org/Homo_sapiens/diseaseview

GeneCards Database http://nciarray.nci.nih.gov/cgi‐bin/cards/listdiseasecards?search=5&type=chrom

Marshfield Clinic/Center for Medical Genetics http://research.marshfieldclinic.org/genetics

NCBI Entrez Map View http://www.ncbi.nlm.nih.gov/cgi‐bin/Entrez/maps.cgi?org=hum&chr=5

Online Mendelian Inheritance in Man (OMIM) Database http://www3.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM

UCSC Genome Bioinformatics Genome Browser http://genome.ucsc.edu

Survival of motor neuron 1 telomeric (SMN1); Locus ID: 6606 LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6606

Survival of motor neuron 1 telomeric (SMN1); MIM number: 600354 OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600354

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How to Cite close
Cheng, Jan‐Fang(Jan 2006) Chromosome 5. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005814]