Bertram Müller‐Myhsok, Bernhard‐Nocht‐Institute for Tropical Medicine, Hamburg, Germany
Andreas Ziegler, University of Lübeck, Lübeck, Germany
Published online: January 2006
DOI: 10.1038/npg.els.0005815
Human chromosome 6 is a submetacentric chromosome, which contains some 5% of the genetic material in the genome. It is characterized by the human major histocompatibility complex(MHC)and a cluster of histone genes.
Keywords: chromosome 6; sequencing; gene cluster; disease; major histocompatibility complex
| References | |
| Venter JC, Adams MD, Myers EW, et al. (2001) The sequence of the human genome. Science 291: 1304–1351. | |
| Further Reading | |
| book Blancher A, Klein J and Socha WW (eds.) (1997) Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Berlin: Springer. | |
| Lander ES, Linton LM, Birren B, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921. | |
| Ziegler A (1997) Biology of chromosome 6. DNA Sequence 8: 189–201. | |
| Web Links | |
| ePath Celera http://www.celera.com | |
| ePath CEPH Genotype database. Database of genotypes for more than 9900 microsatellite markers and more than 1000 SNPs in the CEPH families http://www.cephb.fr/cephdb/ | |
| ePath CEPH-Généthon integrated map. One of several very good genetic maps (see also NCBI) http://www.cephb.fr/ceph-genethon-map.html | |
| ePath Ensembl Genome Browser. An interface for graphical representation of data, including automatic annotation, on a variety of genomes http://www.ensembl.org/ | |
| ePath Ensembl Human Map View. An interface for graphical representation of data, including automatic annotation, on the human genome, here for chromsome 6 http://www.ensembl.org/Homo_sapiens/mapview?chr=6 | |
| ePath Genew. Human Gene Nomenclature Database Search Engine. A gene-based entry point into genomic/genetic as well as disease/phenotype information http://www.gene.ucl.ac.uk/cgi-bin/nomenclature/searchgenes.pl | |
| ePath Genome Database. A classic (human) genome database http://www.gdb.org/ | |
| ePath Genome Monitoring Table http://www.ebi.ac.uk/genomes/mot | |
| ePath HUGO Chromosome 6 Web Page. A dedicated site for chromosome 6, with a very good collection of links. Similar sites are available for the remaining chromosomes at http://www.gdb.org/hugo http://www.gdb.org/hugo/chr6/ | |
| ePath Marshfield Center for Medical Genetics. A major source for data and maps http://research.marshfieldclinic.org/genetics/Map_Markers/maps/IndexMapFrames.html | |
| ePath Mitelman Database of Chromosome Aberrations in Cancer. A database containing information on chromosomal aberrations in cancer http://cgap.nci.nih.gov/Chromosomes/Mitelman | |
| ePath NCBI homepage. The entry point for a whole host of genomics and genetic information, probably the best overall starting point http://www.ncbi.nlm.nih.gov/ | |
| ePath NCBI LocusLink. A single query interface to curated sequences and descriptive information about genetic loci. Contains information on official nomenclature, aliases, sequence accessions, phenotypes, MIM numbers, homology, map locations, related web sites, etc. http://www.ncbi.nlm.nih.gov/LocusLink/ | |
| ePath NCBI SNP database. A very nice and easily usable interface to public SNP information http://www.ncbi.nlm.nih.gov/SNP/index.html | |
| ePath Online Mendelian Inheritance in Man (OMIM). The classic database for the link between diseases/phenotypes and genetic/genomic information http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM) | |
| ePath UCSC Genome Bioinformatics. A very comprehensive source of sequence and related information http://genome.ucsc.edu | |
| ePath Whitehead Institute. A source of information on genetic and physical maps, with a special emphasis on physical maps http://www-genome.wi.mit.edu/cgi-bin/contig/phys_map | |
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