Chromosome 6

Abstract

Human chromosome 6 is a submetacentric chromosome, which contains some 5% of the genetic material in the genome. It is characterized by the human major histocompatibility complex(MHC)and a cluster of histone genes.

Keywords: chromosome 6; sequencing; gene cluster; disease; major histocompatibility complex

References

Venter JC, Adams MD, Myers EW, et al. (2001) The sequence of the human genome. Science 291: 1304–1351.

Further Reading

Blancher A, Klein J and Socha WW (eds.) (1997) Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Berlin: Springer.

Lander ES, Linton LM, Birren B, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921.

Ziegler A (1997) Biology of chromosome 6. DNA Sequence 8: 189–201.

Web Links

Celera http://www.celera.com

CEPH Genotype database. Database of genotypes for more than 9900 microsatellite markers and more than 1000 SNPs in the CEPH families http://www.cephb.fr/cephdb/

CEPH‐Généthon integrated map. One of several very good genetic maps (see also NCBI) http://www.cephb.fr/ceph‐genethon‐map.html

Ensembl Genome Browser. An interface for graphical representation of data, including automatic annotation, on a variety of genomes http://www.ensembl.org/

Ensembl Human Map View. An interface for graphical representation of data, including automatic annotation, on the human genome, here for chromsome 6 http://www.ensembl.org/Homo_sapiens/mapview?chr=6

Genew. Human Gene Nomenclature Database Search Engine. A gene‐based entry point into genomic/genetic as well as disease/phenotype information http://www.gene.ucl.ac.uk/cgi‐bin/nomenclature/searchgenes.pl

Genome Database. A classic (human) genome database http://www.gdb.org/

Genome Monitoring Table http://www.ebi.ac.uk/genomes/mot

HUGO Chromosome 6 Web Page. A dedicated site for chromosome 6, with a very good collection of links. Similar sites are available for the remaining chromosomes at http://www.gdb.org/hugo http://www.gdb.org/hugo/chr6/

Marshfield Center for Medical Genetics. A major source for data and maps http://research.marshfieldclinic.org/genetics/Map_Markers/maps/IndexMapFrames.html

Mitelman Database of Chromosome Aberrations in Cancer. A database containing information on chromosomal aberrations in cancer http://cgap.nci.nih.gov/Chromosomes/Mitelman

NCBI homepage. The entry point for a whole host of genomics and genetic information, probably the best overall starting point http://www.ncbi.nlm.nih.gov/

NCBI LocusLink. A single query interface to curated sequences and descriptive information about genetic loci. Contains information on official nomenclature, aliases, sequence accessions, phenotypes, MIM numbers, homology, map locations, related web sites, etc. http://www.ncbi.nlm.nih.gov/LocusLink/

NCBI SNP database. A very nice and easily usable interface to public SNP information http://www.ncbi.nlm.nih.gov/SNP/index.html

Online Mendelian Inheritance in Man (OMIM). The classic database for the link between diseases/phenotypes and genetic/genomic information http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM)

UCSC Genome Bioinformatics. A very comprehensive source of sequence and related information http://genome.ucsc.edu

Whitehead Institute. A source of information on genetic and physical maps, with a special emphasis on physical maps http://www‐genome.wi.mit.edu/cgi‐bin/contig/phys_map

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How to Cite close
Müller‐Myhsok, Bertram, and Ziegler, Andreas(Jan 2006) Chromosome 6. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005815]